Results 21 to 30 of about 149 (149)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Thin finite simple groups [PDF]
Journal of Algebra, 1976 A group G is of characterstic 2 type if F*(M) = O,(M) for each 2-local subgroup M of G. It seems likely that in the near future the problem of determining the finite simple groups will be reduced to the determination of the characteristic 2 type groups.
openaire +4 more sources
Generalized $M^*$-simple groups [PDF]
Rocky Mountain Journal of Mathematics, 2013 Let X be a compact bordered Klein surface of algebraic genus p >= 2, and let G = Gamma*/Lambda be a group of automorphisms of X where Gamma* is an NEC group and Lambda is a bordered surface group. If the order of G is 4q/(q - 2)(p- 1), for q >= 3 a prime number, then the signature of Gamma* is (0;+; [-]; {(2, 2, 2, q)}).
İkikardeş, Sebahattin, Şahin, Recep
openaire +4 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
, 2005 Groups definable in simple theories retain the chain conditions and decomposition properties known from stable groups, up to commensurability. In the small case, if a generic type of G is not foreign to some type q, there is a q-internal quotient. In the supersimple case, the Berline-Lascar decomposition works.
openaire +2 more sources
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
On Multicommutators for Simple Algebraic Groups
Journal of Algebra, 2001 AbstractThere are several examples of groups for which any pair of commutators can be written such that both of them have a common entry, and one can look for a similar property for n-tuples of commutators. Here we answer, for simple algebraic groups over any field, the weaker question, under which condition the set of n-tuples of commutators with one ...
Gordeev, N, Rehmann, Ulf
openaire +3 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source