Results 51 to 60 of about 1,740,788 (255)
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Terminologia e organização do conhecimento: linguagens, vocabulários e sistemas
Linha D'Água, 2021 Este artigo parte do pressuposto de que as ferramentas utilizadas para a organização do conhecimento (tesauros, esquemas de classificação, etc.) podem ser entendidas como recursos terminológicos.
Bruno Almeida
doaj
Tietojärjestelmän ja opetussuunnittelun käsitteiden rekontekstualisaatiota työpaikan koulutuksissa [PDF]
VAKKI Publications, 2020 The topic of this article is changing workplace communication, viewed from the perspective of using new technologies. The focus is on discussions about the implementation and use of a new information system (Peppi) in ...
Liisa Kääntä, Niina Nissilä
doaj
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Knowledge Nodes: the Building Blocks of a Distributed Approach to Knowledge Management [PDF]
, 2002 : In this paper we criticise the objectivistic approach that underlies most current systems for Knowledge Management. We show that such an approach is incompatible with the very nature of what is to be managed (i.e., knowledge), and we argue that this ...
Bonifacio, Matteo +2 more
core +7 more sources
FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
How translators can improve multilingual terminology in a link: teaching case study examples [PDF]
, 2016 Gómez-Camarero, C. y Palomares Perraut, R. (2016). How translators can improve multilingual terminology in a link: teaching case study examples (Poster). En 38th Translating and the Computer Conference (TC38).
Gómez-Camarero, Carmen +1 more
core
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Complexity and Philosophy [PDF]
, 2006 The science of complexity is based on a new way of thinking that stands in sharp contrast to the philosophy underlying Newtonian science, which is based on reductionism, determinism, and objective knowledge.
Cilliers, Paul +2 more
core +1 more source