Results 31 to 40 of about 321 (215)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Combinatorial descriptions of the crystal structure on certain PBW bases [PDF]

open access: yesDiscrete Mathematics & Theoretical Computer Science, 2020
Lusztig's theory of PBW bases gives a way to realize the crystal B(∞) for any simple complex Lie algebra where the underlying set consists of Kostant partitions. In fact, there are many different such realizations, one for each reduced expression for the
Ben Salisbury   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Classification of harmonic homomorphisms between Riemannian three-dimensional unimodular Lie groups [PDF]

open access: yesArab Journal of Mathematical Sciences
Purpose – The purpose of this study is to classify harmonic homomorphisms ϕ : (G, g) → (H, h), where G, H are connected and simply connected three-dimensional unimodular Lie groups and g, h are left-invariant Riemannian metrics.
Zagane Abdelkader   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

A Classification of Compact Cohomogeneity One Locally Conformal Kähler Manifolds

open access: yesMathematics
In this paper, we apply a result of the classification of a compact cohomogeneity one Riemannian manifold with a compact Lie group G to obtain a classification of compact cohomogeneity one locally conformal Kähler manifolds.
Daniel Guan
doaj   +1 more source

RG flow of integrable E-models

open access: yesPhysics Letters B, 2021
We compute the one- and two-loop RG flow of integrable σ-models with Poisson-Lie symmetry. They are characterised by a twist function with 2N simple poles/zeros and a double pole at infinity.
Falk Hassler
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Doubled aspects of generalised dualities and integrable deformations

open access: yesJournal of High Energy Physics, 2019
The worldsheet theories that describe Poisson-Lie T-dualisable σ-models on group manifolds as well as integrable η, λ and β-deformations provide examples of ℰ-models.
Saskia Demulder   +2 more
doaj   +1 more source

Generic simplicity of quantum Hamiltonian reductions

open access: yesComptes Rendus. Mathématique, 2021
Let a reductive group $G$ act on a smooth affine complex algebraic variety $X.$ Let $\mathfrak{g}$ be the Lie algebra of $G$ and $\mu :T^*(X)\rightarrow \mathfrak{g}^*$ be the moment map.
Tikaradze, Akaki
doaj   +1 more source

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