Results 41 to 50 of about 1,265,981 (327)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

From Loop Groups to 2-Groups [PDF]

, 2005
We describe an interesting relation between Lie 2-algebras, the Kac-Moody central extensions of loop groups, and the group String(n). A Lie 2-algebra is a categorified version of a Lie algebra where the Jacobi identity holds up to a natural isomorphism ...
Baez, John C., Crans, Alissa S., Schreiber, Urs, Stevenson, Danny   +3 more
core   +2 more sources

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Compact Lie Groups, Generalised Euler Angles, and Applications

Universe, 2022
This is mainly a review of an intense 15-year long collaboration between the authors on explicit realisations of compact Lie groups and their applications.
Sergio Luigi Cacciatori, Antonio Scotti
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Symmetry analysis of the canonical connection on Lie groups: six-dimensional case with abelian nilradical and one-dimensional center

AIMS Mathematics
In this article, the investigation into the Lie symmetry algebra of the geodesic equations of the canonical connection on a Lie group was continued. The key ideas of Lie group, Lie algebra, linear connection, and symmetry were quickly reviewed. The focus
Nouf Almutiben , Ryad Ghanam, G. Thompson, Edward L. Boone   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Classification of harmonic homomorphisms between Riemannian three-dimensional unimodular Lie groups [PDF]

Arab Journal of Mathematical Sciences
Purpose – The purpose of this study is to classify harmonic homomorphisms ϕ : (G, g) → (H, h), where G, H are connected and simply connected three-dimensional unimodular Lie groups and g, h are left-invariant Riemannian metrics.
Zagane Abdelkader, Osamnia Nada, Kaddour Zegga   +2 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

About Periodic Shunkov Group Saturated with Finite Simple Groups of Lie Type Rank 1

Известия Иркутского государственного университета: Серия "Математика", 2016
The property of group G to be saturated with given set of groups X is a natural generalization of locally-cover definition (in class of locally finite groups) on periodic groups. Locally-finite group, witch has a locally-cover contains from finite simple
A. Shlepkin
doaj