Results 41 to 50 of about 483,435 (318)

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Combinatorial descriptions of the crystal structure on certain PBW bases [PDF]

Discrete Mathematics & Theoretical Computer Science, 2020
Lusztig's theory of PBW bases gives a way to realize the crystal B(∞) for any simple complex Lie algebra where the underlying set consists of Kostant partitions. In fact, there are many different such realizations, one for each reduced expression for the
Ben Salisbury, Adam Schultze, Peter Tingley   +2 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Symmetry analysis of the canonical connection on Lie groups: six-dimensional case with abelian nilradical and one-dimensional center

AIMS Mathematics
In this article, the investigation into the Lie symmetry algebra of the geodesic equations of the canonical connection on a Lie group was continued. The key ideas of Lie group, Lie algebra, linear connection, and symmetry were quickly reviewed. The focus
Nouf Almutiben , Ryad Ghanam, G. Thompson, Edward L. Boone   +3 more
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Classification of harmonic homomorphisms between Riemannian three-dimensional unimodular Lie groups [PDF]

Arab Journal of Mathematical Sciences
Purpose – The purpose of this study is to classify harmonic homomorphisms ϕ : (G, g) → (H, h), where G, H are connected and simply connected three-dimensional unimodular Lie groups and g, h are left-invariant Riemannian metrics.
Zagane Abdelkader, Osamnia Nada, Kaddour Zegga   +2 more
doaj   +1 more source

Disjointness of a simple matrix Lie group and its Lie algebra [PDF]

arXiv, 2022
Let $G$ be a connected closed subgroup of $\mathrm{GL}_n(\mathbb{C})$ which is simple as a Lie group and which acts irreducibly on $\mathbb{C}^n$. Regarding both $G$ and its Lie algebra $\mathfrak{g}$ as subsets of $M_n(\mathbb{C})$, we have $G\cap \mathfrak{g}\neq\emptyset$ if and only if $G$ is a classical group and $\mathbb{C}^n$ is a minuscule ...
arxiv  

A Simple Model of Double Dynamics on Lie Groups [PDF]

, 2019
We study the dynamics of the rigid rotator on the group manifold of SU(2) as an instance of dynamics on Lie groups together with a dual model whose carrier space is the Borel group SB(2,C), the Lie Poisson dual of SU(2). We thus introduce a parent action on the Drinfeldd double of the above mentioned groups, which describes the dynamics of a system ...
openaire   +4 more sources

Molecular Screening of SCN1A‐Related Seizures in Children With Febrile Seizures: Diagnostic Yield and Variant Distribution

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SCN1A‐related seizures first present as febrile seizures (FS). Definitive features emerge later, making early diagnosis challenging. We evaluated the diagnostic yield and clinical characteristics of pathogenic SCN1A variants in FS, and analyzed the effect of variant characteristics on clinical phenotypes required for early ...
Jia Wang, Yang‐Yang Wang, Lin‐Yan Hu, Xiu‐Yu Shi, Wen He, Dan Sun, Baoguang Li, Xiaoming Liu, Sanqing Xu, Lijun Du, Chunhui Tang, Li‐Ping Zou   +11 more
wiley   +1 more source