Results 61 to 70 of about 510,826 (300)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 1977 Simplicity Pattern #8200 to make a misses' unlined jacket or blouson top with long sleeves and pants with straight legs, including illustrations of the finished pieces and information about sizing and construction on the ...
Simplicity Pattern Co.
core +1 more source
El argumento de la simplicidad y los conceptos de espacio y tiempo en Samule Clarke
Tópicos, 2005 La autora de este estudio se propone poner de relieve la importancia del argumento de la simplicidad en el desarrollo de las ideas de espacio y tiempo en Samuel Clarke y su incidencia en el newtonianismo. Así, en primer lugar intenta poner al descubierto
Laura Benítez Grobert
doaj
Beyond Scarcity: Perspectives on Energy Transition
Relations, 2018 Two dominant lines of reasoning in the philosophical debate on energy transition can be described as boundless consumerism (we should find ways to keep growing) and eco-frugality (we should reduce our impact as much as possible). This paper problematizes
Robert Jan Geerts
doaj +1 more source
On simplicity and emergence [PDF]
Psychonomic Bulletin & Review, 2017 Mark Johnson's paper centres around a provocative and sensible point: the simplicity of a change in evolutionary terms does not necessarily map straightforwardly onto the simplicity of that change within aformal system. This commentary discusses these implications in more depth, making the point that it isimportant to consider the level at which an ...
openaire +3 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Simplicity and stability of the first eigenvalue of a (p;q) Laplacian system
Electronic Journal of Differential Equations, 2012 This article concerns special properties of the principal eigenvalue of a nonlinear elliptic system with Dirichlet boundary conditions. In particular, we show the simplicity of the first eigenvalue of $$displaylines{ -Delta_p u = lambda |u|^{alpha-1}
Ghasem A. Afrouzi +2 more
doaj
Perceptual Simplicity: The True Role of Prägnanz and Occam
Gestalt Theory, 2019 In recent years, the concept of simplicity in perception has acquired a leading role, above all thanks to scholars linked to Bayesian modeling and to theories like structural information theory derived from information theory.
Luccio Riccardo
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
COMPLEXITY * SIMPLICITY * SIMPLEXITY [PDF]
“In the midst of order, there is chaos; but in the midst of chaos, there is order”, John Gribbin wrote in his book Deep Simplicity (p.76). In this dialectical spirit, we discuss the generative tension between complexity and simplicity in the theory and ...
Cunha, Miguel Pina e, Rego, Armenio
core