Results 61 to 70 of about 3,709,326 (303)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Topological effects in ring polymers: A computer simulation study

, 1998
Unconcatenated, unknotted polymer rings in the melt are subject to strong interactions with neighboring chains due to the presence of topological constraints. We study this by computer simulation using the bond-fluctuation algorithm for chains with up to
A. Kolinski, A. Kolinski, A. Kolinski, A. Kolinski, C. R. Bartels, D. Gersappe, D. Richter, E. F. Casassa, G. B. McKenna, G. B. McKenna, G. Hadziioannou, H.-P. Deutsch, H.L. Frisch, I. Carmesin, J. D. Ferry, J. des Cloizeaux, J. Klein, J. Klein, J. P. Wittmer, J. Reiter, J. Roovers, J. Roovers, J. Roovers, J. S. Shaffer, J. Wittmer, K. Dogson, K. S. Schweizer, K. S. Schweizer, K. S. Schweizer, M. Antonietti, M. Doi, M. E. Cates, M. E. Fisher, M. G. Brereton, M. Müller, M.E. Cates, P. J. Mills, S. F. Tead, S. Geyler, T. P. Lodge, T. Pakula, T. Pakula, T. Pakula, W. Burchard, W. Paul, W. Paul   +45 more
core   +1 more source

Space Charge Modelling in Solid Dielectrics under High Electric Field Based on Double Charge Injection Model [PDF]

, 2005
Present study aims to develop a clear insight on factors that influence space charge dynamics in solid dielectrics through a numerical simulation. The model used for the simulation is proposed by Alison and Hill [1] which describes charge dynamics as a ...
Chen, G, Loi, S H
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD4+ T Cell Regulatory Network Underlies the Decrease in Th1 and the Increase in Anergic and Th17 Subsets in Severe COVID-19

Pathogens, 2022
In this model we use a dynamic and multistable Boolean regulatory network to provide a mechanistic explanation of the lymphopenia and dysregulation of CD4+ T cell subsets in COVID-19 and provide therapeutic targets.
Mariana Esther Martinez-Sánchez, José Alberto Choreño-Parra, Elena R. Álvarez-Buylla, Joaquín Zúñiga, Yalbi Itzel Balderas-Martínez   +4 more
doaj   +1 more source

Stability of Ca-montmorillonite hydrates: A computer simulation study

, 2005
Classic simulations are used to study interlayer structure, swelling curves, and stability of Ca-montmorillonite hydrates. For this purpose, NPzzT$ and MuPzzT ensembles are sampled for ground level and given burial conditions. For ground level conditions,
Chatterji S., Frenkel D., G. Odriozola, J. F. Aguilar, Marshall C. E., McEwan D., Newman A. C.D., van Olphen H., van Olphen H.   +8 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Use of functional near-infrared spectroscopy to evaluate cognitive change when using healthcare simulation tools [PDF]

, 2019
This is an accepted manuscript of an article published by BMJ on 01/11/2020, available online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936993/ The accepted version of the publication may differ from the final published version.Background The use ...
Bollard, Martin, Kneafsey, Rosie, Taylor, Natasha, Wyres, Martyn   +3 more
core   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Superprotonic phase transition of CsHSO4: A molecular dynamics simulation study [PDF]

, 2005
The superprotonic phase transition (phase II --> phase I; 414 K) of cesium hydrogen sulfate, CsHSO4, was simulated using molecular dynamics with the "first principles" MSXX force field (FF).
Chisholm, Calum R. I., Goddard, William A., III, Haile, Sossina M., Jang, Yun Hee   +3 more
core   +1 more source