Results 61 to 70 of about 119,339 (216)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

The stability of IRT parameters under several test equating conditions

open access: yesFrontiers in Psychology
IntroductionIt is crucial for researchers and test developers to compare results from different test sets (e. g., re-testing, parallel test forms). To ensure comparability, test sets are often linked using anchor items as a common denominator alongside ...
Dominik Weber   +3 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

A Single-Indicator Factor Approach for Correcting Measurement Error in Time-Varying Predictors in Developmental Research

open access: yesBehavioral Sciences
Composite scores (e.g., mean or sum of survey items) are widely used as outcomes or predictors in psychological and social science research despite methodological concerns regarding measurement error.
Kejin Lee
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Proportionality, Integration Effect, and Legitimacy of the Electoral System to the Czech Chamber of Representatives: A Simulation Study of the Impacts of D0146Hondt divisor, Imperiali Quota and Hare Quota

open access: yesSociologický Časopis
Although the change in the electoral system used in elections to the Chamber of Deputies has attracted the attention of lawyers, political scientists, and sociologists, we still lack a comprehensive comparative analysis of the new system with the ...
Filip Horák   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

A Study of Two Parameter Based an Exponential Probability Distribution: Properties and Applications

open access: yesEngineering Reports
Defined on negative as well as positive domain, we introduce a novel two‐parameter survival distribution to offer enhanced flexibility and applicability in statistical modeling in the article understudy.
Sadaf Khan   +7 more
doaj   +1 more source

Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

open access: yeseLife
Translation failure, in which promising animal study results cannot be reproduced in human trials, is a challenge in biomedical research. Metrics for replication success are widely used to evaluate reproducibility, that is the extent to which the results
Carolyne Jie Huang   +4 more
doaj   +1 more source

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