Results 31 to 40 of about 962,172 (272)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Outreach simulation for system improvement: a novel advocacy and reporting process

Advances in Simulation
Introduction Healthcare simulation programmes measuring their value risk wasting resources in attempts to prove they impact patient outcomes. Simulation is one of many strategies used to enhance healthcare systems, and proving specific correlation with ...
A. St-Onge-St-Hilaire, B. Lawton, L. Dodson, J. Acworth, D. Hufton, B. Symon   +5 more
doaj   +1 more source

Cadaveric simulation for improving surgical training in dermatology. [PDF]

, 2018
Simulation models are rapidly changing medical education, especially the training of dermatology residents. Various models are available, including cadaveric simulations.
Connolly, Deirdre, Griffin, Thomas, Hazan, Ezra, Keller, Matthew, Torbeck, Richard, Trufant, Joshua, Wang, Jordan V.   +6 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Understanding the Role of Achievements in Game-Based Learning

International Journal of Serious Games, 2016
The objective of the current research was to examine whether one potentially effective gaming strategy—achievements—has a positive impact on learning in a game-based environment. An achievement in a video game is a reward or recognition earned by players
Lucas Blair, Clint Bowers, Janis Cannon-Bowers, Emily Gonzalez-Holland   +3 more
doaj   +1 more source

The efficacy and safety of acupuncture and nicotine replacement therapy for smoking cessation: study protocol for a randomized controlled trial

Trials, 2022
Introduction Tobacco hazard is one of the most serious public health problems, accounting for up to 6 million deaths worldwide p.a. We aim to determine the efficacy and safety of acupuncture and/or nicotine replacement therapy on smoking cessation ...
Qingsheng Wang, Runjing Dai, Hailiang Zhang, Xiaomei Jiang, Xiaojing Ma, Xiangrong Zhang, Shisan Bao, Dong Ren, Jingchun Fan   +8 more
doaj   +1 more source

PRE-scripted debriefing for Paediatric simulation Associated with Resuscitation EDucation (PREPARED): A multicentre, cluster randomised controlled trial

Resuscitation Plus, 2022
Aim: Scripted debriefing tools may improve the performance of novices debriefing in resuscitation courses, but this has not previously been measured. The aim of this study was to determine the impact of a script on the quality of debriefs in a statewide ...
Peter J. Snelling, Louise Dodson, Emily Monteagle, Robert S. Ware, Jason Acworth, Ben Symon, Ben Lawton   +6 more
doaj   +1 more source

Proficiency-Based Cervical Cancer Brachytherapy Training: An Effort to Combat Recent Trends in Radiation Oncology That Result in Worse Outcomes for an Underserved Population through Resident Education [PDF]

, 2017
Radiation therapy is the mainstay of treatment for women with cervical cancer with disease outside of the uterine cervix. To deliver the high doses needed for cure, brachytherapy (BT) is necessary to avoid toxicity to normal tissues (1).
Fields, Emma
core   +1 more source

The effects of laryngeal mask airway passage simulation training on the acquisition of undergraduate clinical skills: a randomised controlled trial [PDF]

, 2011
Background\ud Effective use of the laryngeal mask airway (LMA) requires learning proper insertion technique in normal patients undergoing routine surgical procedures.
A Choyce, A Timmermann, AJ Byrne, C du Boulay, Celia A Taylor, DG Altman, DG Altman, DJ Reinhart, DS Ander, Elpiniki Laiou, F Latorre, I Roberts, JH Pennant, JM Murray, KR Stringer, L Tiah, N Weksler, NJ Maran, PM Tolley, PR Davies, R Garcia-Guasch, R Kneebone, Richard J Lilford, RJ Frascone, S Hamaguchy, SB Issenberg, SF Dierdorf, The Laryngeal Mask Company Limited, Thomas H Clutton-Brock, TM Cook, VM Vertongen, Z Morse   +31 more
core   +3 more sources

Biomechanically Compliant Gynecologic Training Simulator

Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare, 2022
Introduction Pap smear training is commonly conducted using simulators before practicing with humans. Unfortunately, existing simulators do not well simulate the biomechanical properties of pelvic tissues, and this may negatively impact the training outcome.
Nadhif, MH, Irsyad, M, Ocviyanti, D
openaire   +3 more sources