Results 111 to 120 of about 125,136 (305)
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
A Mathematical Model of Retinal Receptive Fields Capable of Form & Color Analysis [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2004 In an effort to understand the workings of the retinal receptive fields, Enroth-Cugell and Robson developed a mathematical model that utilized the difference-of-Gaussian (DOG) function, an equation in which the inhibitory portion of a receptive field is ...
John Krantz, Sarah N. Blythe
doaj
"On the Asymptotic Optimality of the LIML Estimator with Possibly Many Instruments" [PDF]
We consider the estimation of the coefficients of a linear structural equation in a simultaneous equation system when there are many instrumental variables.
Naoto Kunitomo +2 more
core
Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli +5 more
wiley +1 more source
Consumers' Preferences for GM Food and Voluntary Information Acquisition: A Simultaneous Choice Analysis [PDF]
Previous research studies directed at the influence of information on consumers' preferences and choices of food in the context of genetically modified (GM) food assume that information is exogenous, in that this is provided to consumers from external ...
Adamowicz, Wiktor L. +2 more
core +1 more source
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
"An Optimal Modification of the LIML Estimation for Many Instruments and Persistent Heteroscedasticity" [PDF]
We consider the estimation of coefficients of a structural equation with many instrumental variables in a simultaneous equation system. It is mathematically equivalent to an estimating equation estimation or a reduced rank regression in the statistical ...
Naoto Kunitomo
core
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao +5 more
wiley +1 more source
The optimal prediction simultaneous equation model selection [PDF]
Notes on unsolved problems The standard linear simultaneous equation model is considered. a) The problem is to compare analytically the estimated reduced (unrestricted and derived) and the structural form of SEM from prediction point of view (for ...
Alexander Gorobets
core