Results 61 to 70 of about 61,494 (263)

Dynamic loads and interference between meshing pairs in multi-stage geared system

Nihon Kikai Gakkai ronbunshu
Inside realistic multi-stage geared system the dynamic meshing tooth loads are in interference mutually between meshing pairs. This report deals with this multi-stage crosstalk theoretically by Receptance Operator Procedure (ROP) that has been developed ...
Masakazu KOJIMA
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modelling and Simulation of Ternary Liquid-Phase Adsorption onto Activated Carbon

Adsorption Science & Technology, 2004
A computational procedure is presented for solving the set of rigid hyperbolic and parabolic partial differential equations describing the simultaneous adsorption of a ternary system in a column packed with adsorbent particles using the non-linear ...
Olaosebikan A. Olafadehan, Alfred A. Susu   +1 more
doaj   +1 more source

Beveridge Curve Shifts – Europe 2020 Perspectives

Scientific Annals of Economics and Business, 2016
The present paper aligns to the economic policy body of research granting intensive efforts to the sphere of analysing the unemployment rate’s evolution as well as its primary drivers and effects in the context of the Europe 2020 strategy.
Ferent-Pipas Marina
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Role of Financial Development Factors on How to Affect Oil Price on Oil and Gas Rents in Iran [PDF]

پژوهشهای اقتصادی, 2020
This paper investigates the role of financial development factors on how to affect oil price on oil and gas rents in Iran. In order to construct a multidimensional financial development index, the principal component analysis and weighted average of nine
fateme shamsolahrar fard, Majid Ahmadian, Nafiseh Behradmehr, Mohsen Mehrara, Ghahraman Abdoli   +4 more
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Multiple Nonlinear Oscillations in a 𝔻3×𝔻3-Symmetrical Coupled System of Identical Cells with Delays

Abstract and Applied Analysis, 2013
A coupled system of nine identical cells with delays and 𝔻3×𝔻3-symmetry is considered. The individual cells are modelled by a scalar delay differential equation which includes linear decay and nonlinear delayed feedback.
Haijun Hu, Li Liu, Jie Mao
doaj   +1 more source