Results 81 to 90 of about 19,870,756 (302)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Assessing the Magnitude of the Concentration Parameter in a Simultaneous Equations Model [PDF]

Poskitt and Skeels (2003) provide a new approximation to the sampling distribution of the IV estimator in a simultaneous equations model. This approximation is appropriate when the concentration parameter associated with the reduced form model is small ...
C. L. Skeels, D. S. Poskitt
core  

The Role of Financial Development Factors on How to Affect Oil Price on Oil and Gas Rents in Iran [PDF]

پژوهشهای اقتصادی, 2020
This paper investigates the role of financial development factors on how to affect oil price on oil and gas rents in Iran. In order to construct a multidimensional financial development index, the principal component analysis and weighted average of nine
fateme shamsolahrar fard, Majid Ahmadian, Nafiseh Behradmehr, Mohsen Mehrara, Ghahraman Abdoli   +4 more
doaj  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

INFORMATION THEORETIC ALTERNATIVES TO TRADITIONAL SIMULTANEOUS EQUATIONS ESTIMATORS IN THE PRESENCE OF HETEROSKEDASTICITY [PDF]

Finite sampling properties of information theoretic estimators of the simultaneous equations model, including maximum empirical likelihood, maximum empirical exponential likelihood, and maximum log Euclidean likelihood, are examined in the presence of ...
Mittelhammer, Ronald C., Marsh, Thomas L.   +1 more
core  

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Multiple Nonlinear Oscillations in a 𝔻3×𝔻3-Symmetrical Coupled System of Identical Cells with Delays

Abstract and Applied Analysis, 2013
A coupled system of nine identical cells with delays and 𝔻3×𝔻3-symmetry is considered. The individual cells are modelled by a scalar delay differential equation which includes linear decay and nonlinear delayed feedback.
Haijun Hu, Li Liu, Jie Mao
doaj   +1 more source

FAKTOR-FAKTOR YANG MEMENGARUHI PDB INDONESIA DENGAN PERSAMAAN SIMULTAN 2SLS

E-Jurnal Matematika, 2012
Economic growth is indicated by an increase in the value of Gross Domestic Product (GDP). The size of GDP is influenced by various factors, including the Household Consumption, Investment, Government Spending, and Net Exports.
NI MADE SRI KUSUMAWARDHANI, I GUSTI AYU MADE SRINADI, MADE SUSILAWATI   +2 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source