Results 41 to 50 of about 19,373 (299)

Deliberation without sincerity [PDF]

, 2014
Sincerity is considered a key notion within theories of deliberative democracy and a crucial feature of public reason approaches that give deliberation a prominent role. However, few theorists have put forward a clear and definite account for it.
G. Bistagnino
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Apology and Sincerity [PDF]

, 2019
When studying the apology as a speech act, the notion of sincerity becomes central for the investigation. In the literature, sincerity has been understood as a matter of correspondence between words and mind.
Lindblom, Oskar
core  

Sincerity After Communism

, 2017
This book presents the compelling study of “new sincerity” as a powerful cultural practice, born in perestroika-era Russia, and how it interconnects with global social and media flows.
Ellen Rutten
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Problems of Sincerity [PDF]

, 2005
It is undeniable that the assumption of sincerity is important to assertion, and that assertion is central to the transmission of beliefs through human testimony.
Moran, Richard
core   +1 more source

Victim-Focused Political Apology Predicts Political Support via Perceived Sincerity, Trust and Positive Emotional Climate: The Case of the 2018 Bushfire in Attica

Journal of Social and Political Psychology, 2022
Political leaders tend to apologize for wrongdoings. This study focuses on a disaster that occurred on July 2018 in east Attica, Greece, where wildfires destroyed houses and left dozens of people dead.
Theofilos Gkinopoulos
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

From Social Performance to Expressing the ‘True Self’: The Change in the Communicational Assumptions in Polish Letter-Writing Manuals from the Eighteenth and the Early Nineteenth Centuries in the Context of the Emergence of Modern Sincerity in the West

European Journal of Life Writing, 2020
While the traditional model of verbal expression was founded on the premise that individuals should skilfully use conventions in order to achieve their goals, the modern approach, based on sincerity, assumes that people should problematise the truth ...
Agata Sikora
doaj   +1 more source