Advanced Science, EarlyView.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
Correction: Remodeling tumor microenvironment using prodrug nMOFs for synergistic cancer therapy. [PDF]
J NanobiotechnologyDong J +9 more
europepmc +1 more source
Incidence of chronic wounds in Singapore, a multiethnic Asian country, between 2000 and 2017: a retrospective cohort study using a nationwide claims database [PDF]
, 2020 Orlanda Goh +5 more
openalex +1 more source
Knowledge Sources of Innovation in a Small, Open Economy: The Case of Singapore [PDF]
By tracing the flows of patent citation of prior patents and scientific journal articles, we investigate the sources of knowledge for innovation output in Singapore, a small, highly open economy that has traditionally been significantly dependent on ...
Poh Kam Wong, Yuen Ping Ho
core
A Closed‐Loop Hybrid Discovery System of Type I Photosensitizers for Hypoxic Tumor Therapy
Advanced Science, EarlyView.The work developed a closed‐loop hybrid discovery system to rationally design and predict high‐performance Type I PSs for hypoxic tumor therapy. 664 Potential candidates are identified from a dataset through a support vector machine (SVM) classification model, and two candidates are experimentally verified as Type I PSs, which highlighted the potential
Xia Ling +9 more
wiley +1 more source
The dynamics of divorce, income, and female labor force participation in Singapore. [PDF]
Singapore has experienced rising income and female labor force participation over the years. This growth, however, is also accompanied by increasing divorce rate.
Lee Chew Ging, Ng Pek Kim
core
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis
Advanced Science, EarlyView.OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu +17 more
wiley +1 more source
Effectiveness of a Customized Peritoneal Dialysis Training Program in Reducing Infection and Dropout Rates: Insights From a Singapore Hospital [PDF]
Peishan Lee +5 more
openalex +1 more source