Results 191 to 200 of about 651,227 (267)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

CANTAO: guiding clustering and annotation in single-cell RNA sequencing using average overlap. [PDF]

Mol Syst Biol
Thai C, Singh A, Herranz D, Khiabanian H.   +3 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Single-Cell RNA Sequencing Reveals the Therapeutic Effects of Electroacupuncture at BL23 on Hyperuricemia-Induced Nephritis. [PDF]

Int J Genomics
Hu Y, Song X, Li H, Zhao S.
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy. [PDF]

Nat Commun
Fernandez B, Passanisi VJ, Ashraf HM, Spencer SL.   +3 more
europepmc   +1 more source

MULTIPLE MYELOMA PLASMA CELL PROFILING: INTEGRATED SINGLE-CELL RNA AND VDJ SEQUENCING APPROACHES UNCOVER NOVEL CLINICAL INSIGHTS

N. Bolli, C. Sforza, A. Matera
openalex   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Deciphering immune features and cellular heterogeneity in PRRSV infection via single-cell RNA sequencing. [PDF]

J Virol
Li J, Liang Y, Zhang Y, Xu Y, Liu F, Ding L, Wang Y, Zhang Z, Chen Z, Sun W, Yu J, Wu J.   +11 more
europepmc   +1 more source

Integrated single-cell and bulk RNA sequencing reveals the mechanisms of electroacupuncture in suppressing ferroptosis after spinal cord injury

Jieqi Zhang, Yi Huang, Xihan Ying, Ruoqi Wang, Kai Zhang, Lei Wu, Dexiong Han, Ruijie Ma, Kelin He   +8 more
openalex   +1 more source