Results 51 to 60 of about 31,349 (221)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Engineering Mononuclear Ln(III) Complexes with a Pseudo-Macrocyclic Hexadentate N₄O₂ Schiff Base Ligand Exhibiting Slow Magnetic Relaxation

Magnetochemistry
We report here the synthesis of a series of nine coordinated mononuclear LnIII complexes [LnL1Cl2(DMF)]Cl·2.5DMF and [LnL1(L2)2]Cl·4CH3OH (LnIII = GdIII, DyIII, ErIII and YbIII, HL2 = 9-anthracenecarboxylic acid), where L1 is a hexadentate N4O2 Schiff ...
Ismael Francisco Diaz-Ortega, Yating Ye, Jesus Jover, Eliseo Ruiz, Enrique Colacio, Juan Manuel Herrera   +5 more
doaj   +1 more source

Counterintuitive Single-Molecule Magnet Behaviour in Two Polymorphs of One-Dimensional Compounds Involving Chiral BINOL-Derived Bisphosphate Ligands

Magnetochemistry, 2021
The coordination reaction of the [Dy(hfac)3(H2O)2] units (hfac− = 1,1,1,5,5,5-hexafluoroacetylacetonate) with the [8′-(Diphenoxylphosphinyl)[1,1′-binaphthalen]-8-yl]diphenoxylphosphine oxide ligand (L) followed by a crystallisation in a 1:3 CH2Cl2:n ...
Carlo Andrea Mattei, Bertrand Lefeuvre, Vincent Dorcet, Gilles Argouarch, Olivier Cador, Claudia Lalli, Fabrice Pointillart   +6 more
doaj   +1 more source

Spin-parity dependent tunneling of magnetization in single-molecule magnets

, 2001
Single-molecule magnets facilitate the study of quantum tunneling of magnetization at the mesoscopic level. The spin-parity effect is among the fundamental predictions that have yet to be clearly observed.
A. Caneschi, A. Fort, A. Garg, A.M. Gomes, C. Boskovic, C. Sangregorio, C. Zener, D. Loss, D. N. Hendrickson, D.J. Price, E.M. Chudnovsky, E.M. Chudnovsky, G. Christou, G. Rose, H.A. Kramers, J. von Delft, J. Yoo, J.L. Van Hemmen, J.R. Friedman, L. Bokacheva, L. Landau, L. Thomas, M. Thorwart, M.N. Leuenberger, N.V. Prokof’ev, R. Sessoli, S. Bhaduri, S. Miyashita, S. Miyashita, S.M.J. Aubin, W. Wernsdorfer, W. Wernsdorfer, W. Wernsdorfer, W. Wernsdorfer, W. Wernsdorfer, W. Wernsdorfer, W. Wernsdorfer   +36 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A four-coordinate cobalt(II) single-ion magnet with coercivity and a very high energy barrier

Nature Communications, 2016
Bistable single-molecule magnets potentially allow information storage at extremely high densities. Here, the authors study an air- and moisture-stable mononuclear tetrahedral cobalt(II) complex, elucidating the origin of its pronounced magnetic ...
Yvonne Rechkemmer, Frauke D. Breitgoff, Margarethe van der Meer, Mihail Atanasov, Michael Hakl, Milan Orlita, Petr Neugebauer, Frank Neese, Biprajit Sarkar, Joris van Slageren   +9 more
doaj   +1 more source

Water-oriented magnetic anisotropy transition

Nature Communications, 2021
Little is known about how the orientation of coordinated water molecules affects the magnetic properties of single molecule magnets. Here the authors combine experimental data and theoretical calculations to study how the rotation of water molecules ...
Sheng-Qun Su, Shu-Qi Wu, Masato Hagihala, Ping Miao, Zhijian Tan, Shuki Torii, Takashi Kamiyama, Tongtong Xiao, Zhenxing Wang, Zhongwen Ouyang, Yuji Miyazaki, Motohiro Nakano, Takumi Nakanishi, Jun-Qiu Li, Shinji Kanegawa, Osamu Sato   +15 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source