Results 71 to 80 of about 5,474,145 (308)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Single atom catalysts: a surface heterocompound perspective

Nanoscale Horizons, 2020
Evolution of heterogeneous catalysts with steady down-sizing: from small particles, clusters, dots to single atoms, and now the “surface heterocompound”.
Zongkui Kou, Wenjie Zang, Peikui Wang, Xin Li, John Wang   +4 more
openaire   +3 more sources

Single‐atom catalysts for the electrochemical reduction of carbon dioxide into hydrocarbons and oxygenates

Carbon Energy
The electrochemical reduction of carbon dioxide offers a sound and economically viable technology for the electrification and decarbonization of the chemical and fuel industries.
Karl Adrian Gandionco, Juwon Kim, Lieven Bekaert, Annick Hubin, Jongwoo Lim   +4 more
doaj   +1 more source

Recent Advances in Multi-Atom Catalysts for Sustainable Energy Applications

Molecules
Single-atom catalysts characterized by their novel electronic configurations and exceptional atomic utilization efficiency have emerged as potential alternatives to costly noble metal catalysts, garnering extensive research attention in various ...
Qing Wang, Bo Cheng, Shichang Cai, Xiaoxiao Li, Di Lu, Naying Zhang, Chaoqun Chen, Hanlu Zhang, Yagang Feng, Lei Duan, Shaoyong Qin, Zihan Meng   +11 more
doaj   +1 more source

Regulating the electronic structure through charge redistribution in dense single-atom catalysts for enhanced alkene epoxidation

Nature Communications, 2023
Inter-site interaction in densely populated single-atom catalysts has been demonstrated to have a crucial role in regulating the electronic structure of metal atoms, and consequently their catalytic performances.
Hongqiang Jin, Kaixin Zhou, Ruoxi Zhang, Hongjie Cui, Yu Yu, Peixin Cui, Weiguo Song, Changyan Cao   +7 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

A perspective on oxide-supported single-atom catalysts

Nanoscale Advances, 2020
To explore oxide-supported single-atom catalysts (SACs) at the atomic level, a recently developed surface free energy approach may help fabricate well-defined SACs to tackle some key issues in the future.
Junyi Zhou, Zhen Xu, Meijia Xu, Xiong Zhou, Kai Wu   +4 more
openaire   +3 more sources

Innovative applications of single-atom catalysts in MgH2/Mg system to build high-efficiency hydrogen storage

Journal of Magnesium and Alloys
MgH2 shows significant potential for a solid-state hydrogen storage medium due to the advantages of high hydrogen capacity, excellent reversibility, and low cost.
Lixiang Ma, Lu Zhang, Zhuohan Zhang, Qiuming Peng, Shumin Han, Yuan Li   +5 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source