Results 121 to 130 of about 3,861,359 (307)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Mapping NK cell diversity in response to COVID-19 and mRNA vaccination
Scientific ReportsHuman NK cells exhibit functional heterogeneity, yet the clinical conditions and cellular processes driving this diversity remain insufficiently understood.
Yosuke Kishi +7 more
doaj +1 more source
Twisted Tales: Insights into Genome Diversity of Ciliates Using Single-Cell 'Omics. [PDF]
, 2018 The emergence of robust single-cell 'omics techniques enables studies of uncultivable species, allowing for the (re)discovery of diverse genomic features.
Katz, Laura A +4 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Heat Shock Factor HSFA6b Mediates Mitochondrial Unfolded Protein Response in Arabidopsis thaliana
PlantsMitochondria are important organelles in eukaryotes and are involved in various metabolic processes. Mitochondrial proteotoxic stress triggers the mitochondrial unfolded protein response (UPRmt) to restore mitochondrial protein homeostasis and maintain ...
Guolong Yu +6 more
doaj +1 more source
Single-Cell Enumeration of an Uncultivated TM7 Subgroup in the [PDF]
, 2003 Specific oligonucleotide hybridization conditions were established for single-cell enumeration of uncultivated TM7 and IO25 bacteria by using clones expressing heterologous 16S rRNA. In situ analysis of human subgingival crevice specimens revealed that a
Armitage, Gary C. +2 more
core +1 more source
Single-cell protein dynamics reproduce universal fluctuations in cell populations
, 2015 Protein variability in single cells has been studied extensively in populations, but little is known about temporal protein fluctuations in a single cell over extended times.
Braun, Erez +5 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The hidden mycobiome: emerging role in anticancer immunotherapy
MycologyAs one of the emerging hallmarks, the mycobiome has recently gained significant recognition in cancer research, especially regarding anticancer immunotherapy.
Ze-Chang Peng +6 more
doaj +1 more source