Results 231 to 240 of about 1,198,587 (324)

Implications of Single-Cell RNA Sequencing in Cervical Cancer: Unravelling the Molecular Landscape. [PDF]

ACS Omega
Kiruba B, Raja Karthikeyan RRR, Anilkumar SR, Sundararajan V, Lulu S S.   +4 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Single-Cell RNA Sequencing Reveals the Cellular and Molecular Differences Between Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma. [PDF]

Med Sci (Basel)
Fetisov TI, Ikonnikov AV, Kopantseva EE, Shtompel PA, Khazanova SA, Trapeznikova ES, Zinovieva VY, Zuevskaya SN, Tararykova AA, Bokhyan BY, Belitsky GA, Lesovaya EA, Yakubovskaya MG, Denisov EV, Kirsanov KI.   +14 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The Distinct Monocyte Subsets and Intercellular Communication in Primary Sjögren's Syndrome Revealed by Single-Cell RNA Sequencing. [PDF]

J Clin Immunol
Zhang X, Song X, Fang L, Zang B, Li J, Yang Y, Xu M, Han Y, Liu Q, Zhu H, Liu B.   +10 more
europepmc   +1 more source

Investigating regulatory T cells by single cell RNA-sequencing [PDF]

, 2014
Ferreira, E. C., Miragaia, Ricardo Júdice, Teichmann, Sarah   +2 more
core  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

scSCCNIA: similarity matrix based contrastive clustering with neighbor information aggregation for single-cell RNA sequencing data. [PDF]

Brief Bioinform
Wang J, Xia J, Su Y, Zheng CH.
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Single-cell RNA sequencing reveals disease associated changes in brain endothelial cells in the 5XFAD mouse. [PDF]

Fluids Barriers CNS
Embalabala RJ, Masters H, Ziehm E, Pouncey J, Kim H, Lippmann ES.   +5 more
europepmc   +1 more source