Results 121 to 130 of about 642,878 (258)

A practical guide to targeted single-cell RNA sequencing technologies. [PDF]

Commun Biol
Moro G, Brunner E, Basler K.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Clinical application of single-cell RNA sequencing in disease and therapy. [PDF]

Clin Transl Med
Nadukkandy AS, Kalaiselvan S, Lin L, Luo Y.   +3 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Single-cell RNA sequencing revealed cell heterogeneity in sagittal suture mesenchyme. [PDF]

Front Cell Dev Biol
Ren C, Sun K, Wu R, Geng C, Chen J, Zhao H, Chen W.   +6 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Deciphering the Osteoimmune Landscape in Subtalar Arthrodesis: A Single-Cell RNA Sequencing Approach. [PDF]

J Cell Mol Med
Lee H, Kim K, Goh TS, Kang SW, Bae JY, Cho SY, Kwon Y, Kim WK, Kim JW, Kim YH, Woo SH.   +10 more
europepmc   +1 more source

Single Cell RNA Sequencing for COPD [PDF]

C108. OMICS OF COPD AND IPF, 2020
X. Li, G. Noell, T. Tabib, A. Gregory, M.E. Snyder, C. Zou, R. Vats, P. Sundd, D. Chandra, J.F. McDyer, K. Chen, J. Sembrat, H. Trejo Bittar, Y. Zhang, F.C. Sciurba, M. Rojas, R.A. Lafyatis, S.D. Shapiro, M.R. Faner, T. Nyunoya   +19 more
openaire   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Single-cell RNA sequencing and integrated bioinformatics reveal new mitochondrial biomarkers in sarcopenia. [PDF]

Front Mol Biosci
Ying H, Wang W, Huang L, Hong W, Yang L.
europepmc   +1 more source