Results 261 to 270 of about 731,457 (305)

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Identification of key regulators for the development of Prunus leaves using single-cell RNA sequencing. [PDF]

BMC Plant Biol
Li M, Gao X, Nie P, Li G, Gong Q, Dong X, Zhang A.   +6 more
europepmc   +1 more source

Single-cell RNA sequencing and integrated bioinformatics reveal new mitochondrial biomarkers in sarcopenia. [PDF]

Front Mol Biosci
Ying H, Wang W, Huang L, Hong W, Yang L.
europepmc   +1 more source

Single-cell RNA sequencing reveals immune microenvironment heterogeneity in BRCA1-mutated and sporadic triple-negative breast cancer. [PDF]

Transl Oncol
Sun Q, Zhong Y, Sun C.
europepmc   +1 more source

Single cell RNA-sequencing reveals that testosterone reduces estrogen signaling in the healthy human mammary gland. [PDF]

J Mammary Gland Biol Neoplasia
Phong KT, Song S, Kim EA, Conrad DN, Gartner ZJ.   +4 more
europepmc   +1 more source

Single-cell RNA sequencing analysis revealed a potential association between ELK3 expression and the progression of multiple myeloma. [PDF]

Front Immunol
Song C, Chen T, Yu S, Huang T, Chen T, Wang C, Liang Y.   +6 more
europepmc   +1 more source

Immunomodulatory Mechanism of Baiyaojian Decoction on Periodontitis: Network Pharmacology, Single-Cell RNA Sequencing and Molecular Docking. [PDF]

J Cell Mol Med
Chen BJ, Li MM, Zheng ZY, Jin WQ, Jin Z, Zuo YL.   +5 more
europepmc   +1 more source

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Single Cell RNA Sequencing in NASH

2022
Single cell RNA sequencing (scRNA-seq) allows to uncover cellular heterogeneity and the identification of novel subpopulations. In non-alcoholic steatohepatitis (NASH), scRNA-seq is particularly powerful to understand non-parenchymal cell heterogeneity in the liver, e.g. for inflammatory cells.
Jana Hundertmark, Hilmar Berger, Frank Tacke   +2 more
openaire   +2 more sources

Single-cell RNA sequencing in pancreatic cancer

Nature Reviews Gastroenterology & Hepatology, 2021
The application of single-cell RNA sequencing platforms has generated notable insights into the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing both the neoplastic compartment and the tumour microenvironment. In this Comment, we discuss the most pertinent findings gleaned from both mouse models and human PDAC samples, as ...
Jincheng Han, Ronald A. DePinho, Anirban Maitra   +2 more
openaire   +2 more sources