Results 91 to 100 of about 12,248,518 (326)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Structure and Nonlinear Optical Characterization of a New Acentric Crystal of a 4-Hydroxybenzohydrazide Derivative

Crystals
We report the crystal structure and nonlinear optical (NLO) characterization of the monohydrate form of N′-[(E)-(2-fluorophenyl)methylidene]-4-hydroxybenzohydrazide (o-FHH), an organic compound showing strong potential for second-order nonlinear optical ...
Emanuela Santagata, Yovan de Coene, Stijn Van Cleuvenbergen, Koen Clays, Emmanuele Parisi, Fabio Borbone, Roberto Centore   +6 more
doaj   +1 more source

Controlled Growth of Single‐Crystal Graphene Films

Advances in Materials, 2019
Grain boundaries produced during material synthesis affect both the intrinsic properties of materials and their potential for high‐end applications. This effect is commonly observed in graphene film grown using chemical vapor deposition and therefore ...
Jincan Zhang, Li Lin, Kaicheng Jia, Luzhao Sun, H. Peng, Zhongfan Liu   +5 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Formation Mechanisms of Chilled Layer on the Perimeter of Superalloy Seed

Metals
The seeding technique is the only way to precisely control the crystal orientation of single-crystal superalloy castings. However, an inevitable assembly gap exists between the seed and the mold cavity in practice, whose role in defect formation remains ...
Yangpi Deng, Dexin Ma, Jianhui Wei, Yunxing Zhao, Lv Li, Bowen Cheng, Fuze Xu   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

2-Methyl-4-[(4-methylphenyl)amino]benzoic acid

IUCrData
In the title compound, C15H15NO2, which was prepared using a Buchwald–Hartwig cross-coupling reaction followed by ester hydrolysis, the dihedral angle between the aromatic rings is 42.44 (7)°.
Fang He, Sihui Long
doaj   +1 more source

Growth and Characterization of Tetraphenylphosphonium Bromide Crystal

Crystals, 2017
Multiple-phenyl phosphorous compounds are a group of chemical materials that have been used as reactants, pharmaceutical intermediates, extractants, and catalysts in organic synthetic reactions.
Guangqiang Wang, Xiaolong Liu, Yan Ren, Chengqian Zhang, Xutang Tao   +4 more
doaj   +1 more source

Single Crystal Membranes [PDF]

Single crystal a- and c-axis tubes and ribbons of sodium beta-alumina and sodium magnesium beta-alumina were grown from sodium oxide rich melts. Additional experiments grew ribbon crystals containing sodium magnesium beta, beta double prime, beta triple ...
Morrison, A., Stormont, R. W.
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source