Results 71 to 80 of about 12,248,518 (326)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

X-ray Crystallography, DFT Calculations and Molecular Docking of Indole-Arylpiperazine Derivatives as α1A-Adrenoceptor Antagonists

Molecules, 2015
Indole-arylpiperazine derivatives have exhibited good selectivity for the α1A-adrenoceptor, but the structure-activity-binding mechanism relationship remains unclear.
Wei Xu, Jun-Jun Huang, Bin-Hao Shao, Xing-Jie Xu, Ren-Wang Jiang, Mu Yuan   +5 more
doaj   +1 more source

Growth of single-crystal gallium nitride [PDF]

, 1970
Use of ultrahigh purity ammonia prevents oxygen contamination of GaN during growth, making it possible to grow the GaN at temperatures as high as 825 degrees C, at which point single crystal wafers are deposited on /0001/-oriented sapphire ...
Clough, R., Richman, D., Tietjen, J.
core   +1 more source

Large single crystal growth of BaFe1.87Co0.13As2 using a nucleation pole

, 2009
Co-doped iron arsenic single crystal of BaFe1.87Co0.13As2 with dimension up to 20 x 10 x 2 mm3 were grown by a nucleation pole: an alumina stick served as nucleation center during growth.
C T Lin, D L Sun, J T Park, Li J, Luo H Q, Sun G L Sun D L Konuma M Popovich P Boris A Peng J B Choi K Y Lemmens P Lin C T, Wen H H, Y Liu, Zhigadlo N D   +8 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Magnetization hysteresis and time decay measurements in FeSe$_{0.50}$Te$_{0.50}$ : Evidence for fluctuation in mean free path induced pinning

, 2011
We present results of magnetic measurements relating to vortex phase diagram in a single crystal of FeSe$_{0.5}$Te$_{0.5}$ which displays second magnetization peak anomaly for $H \parallel c$.
A. I. Larkin, A. K. Grover, A. M. Campbell, Ajay D. Thakur, Anil K. Yadav, C. P. Poole Jr., C. V. Tomy, D. Pal, G. Balakrishnan, M. R. Lees, P. Das, S. Ramakrishnan   +11 more
core   +1 more source

Structural response to O*-O' and magnetic transitions in orthorhombic perovskites [PDF]

, 2002
We present a temperature dependent single crystal x-ray diffraction study of twinned orthorhombic perovskites La1-xCaxMnO3, for x=0.16 and x=0.25. These data show the evolution of the crystal structure from the ferromagnetic insulating state to the ...
A. von Hippel, Auke Meetsma, B. Dabrowski, B. Dabrowski, Bas B. Van Aken, C. Williams, E. Liarokapis, G.A. de Wijs, J. Alonso, J. Kanamori, J. Rodríguez-Carvajal, J.B. Goodenough, J.B. Goodenough, J.B.A.A. Elemans, M. Dechamps, M. Marezio, N.D. Mathur, P.G. Radaelli, Q. Huang, R.D. Shannon, S.J. Hibble, S.J.L. Billinge, T. Mizokawa, Thomas T. M. Palstra, V.M. Goldschmidt, Y. Murakami, Y. Tokura, Y. Tomioka, Y. Yamada   +28 more
core   +4 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Crystal structure of AlPCl8

Acta Crystallographica Section E: Crystallographic Communications
The crystal structure of aluminium phosphorus chloride (systematic name: phosphorus tetrachloride tetrachloridoaluminate), (PCl4)[AlCl4] or AlPCl8, was determined and refined using single-crystal X-ray diffraction data.
Hyeonjin Seo, Seungyong Shin, Seung-Tae Hong   +2 more
doaj   +1 more source

Crystal structures of the bis-bidentate N2S2 Schiff base ligand and its copper(I) coordination polymer

Macedonian Journal of Chemistry and Chemical Engineering, 2019
A new flexible bis-bidentate N2S2 Schiff base ligand (2,4-Cl-ba)2dapte = N,Nʹ-bis-(2,4-dichlorobenzaldehyde)-1,2-di(o-iminophenylthio)ethane and its copper(I) coordination polymer [Cu2(μ-I)2(μ-(2,4-Cl-ba)2dapte)]n, were synthesized and characterized by ...
Aliakbar Dehno Khalaji, Seyyed Javad Peyghoun, Michal Dusek, Monika Kucerakova, Alireza Akbari, Nourollah Feizi   +5 more
doaj   +1 more source