Results 211 to 220 of about 993,390 (258)

Non-linear relationships between inflammatory indices and erectile dysfunction in a group of young men living with HIV. [PDF]

Basic Clin Androl
Tiecco G, Riva M, Cesanelli F, Rossi L, Colangelo C, Reale SA, Gottardi F, Delbarba A, Cappelli C, Focà E, Castelli F, Quiros-Roldan E.   +11 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Machine Learning-Based Survival Prediction Models for Young Patients With Gastric Cancer: Model Development and Validation Study. [PDF]

JMIR Cancer
Kang HYJ, Jang W, Ko M, Ryu KS.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Integrating Lateral Super-Resolution and Axial Progression Reveals Distinct Clathrin Pit Formation Pathways. [PDF]

Traffic
Thompson C, Mondal A, Lafyatis G, Kural C.   +3 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Systemic Lupus International Collaborating Clinics Frailty Index predicts mortality in systemic lupus erythematosus patients: data from the Almenara Lupus Cohort. [PDF]

Lupus Sci Med
Rashuamán-Conche BH, Gamboa-Cárdenas RV, Pimentel-Quiroz VR, Singh A, Reátegui-Sokolova C, Elera-Fitzcarrald C, Garcia-Hirsh S, Pastor-Asurza C, Rodríguez-Bellido Z, Perich-Campos RA, Alarcón GS, Ugarte-Gil MF.   +11 more
europepmc   +1 more source

Sex-Specific Associations of Triglyceride-Glucose Index and a Body Shape Index with Cardiometabolic Multimorbidity Risk: A Prospective Cohort Study. [PDF]

J Clin Med
Liu T, Li Y, Huang Y, Pan A, Yin J, Liao Y.   +5 more
europepmc   +1 more source

A multidimensional biomarker model of vitality and its associations with intrinsic capacity and frailty. [PDF]

J Nutr Health Aging
Chew J, Chia JQ, Lim JP, Yeo A, Tan CN, Chan SP, Lim CL, Lim WS.   +7 more
europepmc   +1 more source