Results 181 to 190 of about 15,189,898 (202)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

On Single-Index Coefficient Regression Models

Journal of the American Statistical Association, 1999
In this article we investigate a class of single-index coefficient regression models under dependence. This includes many existing models, such as the smooth transition threshold autoregressive (STAR) model of Chan and Tong, the functional-coefficient ...

exaly   +4 more sources

Optimal Smoothing in Single-Index Models

Annals of Statistics, 1993
Single-index models generalize linear regression. They have applications to a variety of fields, such as discrete choice analysis in econometrics and dose response models in biometrics, where high-dimensional regression models are often employed.
Wolfgang Härdle, Hidehiko Ichimura
exaly   +2 more sources

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Distributional (Single) Index Models

Journal of the American Statistical Association, 2023
Alexander Henzi, Johanna Ziegel, Gian-Reto Kleger   +2 more
exaly  

A Functional Varying-Coefficient Single-Index Model for Functional Response Data

Journal of the American Statistical Association, 2017
Chao Huang, Hongtu Zhu
exaly  

Penalized least squares for single index models

Journal of Statistical Planning and Inference, 2011
Heng Peng
exaly  

Access Suspended

Annals of Statistics, 2016
Jiti Gao, Chaohua Dong, Dag Tjøstheim
exaly  

Empirical likelihood for single index model with missing covariates at random

Statistics, 2015
Xu Guo, Wangli Xu, Cuizhen Niu
exaly