Results 151 to 160 of about 15,278,209 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Predicting spring maize yield using UAV remote sensing

Guan'gai paishui xuebao
【Objective】Predicting potential crop yield is critical not only to policy making but also to improving agricultural management to safeguard food production.
MA Shijiao, FANG Chengtai, ZHAO Jinghua, LIU Feng, YANG Tingrui, YUAN Ruxin   +5 more
doaj   +1 more source

Learning Single Index Models with Diffusion Priors

CoRR
ICML ...
Anqi Tang, Youming Chen, Shuchen Xue, Zhaoqiang Liu   +3 more
openaire   +4 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single‐center observational cohort study

Aging Medicine
Objectives Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices.
Yanna Yu, Fen Li, Zhan Wang, Zhibin Ni, Shu Zhang, Weihong Zhao, Xiaohua Pei   +6 more
doaj   +1 more source

Large-sample estimation and inference in multivariate single-index models. [PDF]

J Multivar Anal, 2019
Wu J, Peng H, Tu W.
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A hybrid omnibus test for generalized semiparametric single-index models with high-dimensional covariate sets. [PDF]

Biometrics, 2019
Xu Y, Kim I, Carroll RJ.
europepmc   +1 more source

Estimating panel data duration models with censored data [PDF]

, 2005
This paper presents a method for estimating a class of panel data duration models, under which an unknown transformation of the duration variable is linearly related to the observed explanatory variables and the unobserved heterogeneity (or frailty ...
Lee, S.
core