Results 111 to 120 of about 991,751 (258)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Unified Modeling and Multi-Objective Optimization for Disassembly Line Balancing with Distinct Station Configurations

Mathematics
Disassembly line balancing (DLB) is a crucial optimization item in the recycling and remanufacturing of waste products. Considering the variations in the number of operators assigned to each station, this study investigates DLBs with six distinct station
Tao Yin, Yuanzhi Wang, Shixi Cai, Yuxun Zhang, Jianyu Long   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Fine-scale predictive modeling of Aedes mosquito abundance and dengue risk indicators using machine learning algorithms with microclimatic variables

Scientific Reports
Effective prediction of Aedes mosquito abundance and dengue risk indicators such as the Aedes Index (AI) and Dengue Positive Trap Index (DPTI) is essential for early intervention and targeted vector control.
Nazri Che Dom, Nur Athen Mohd Hardy Abdullah, Rahmat Dapari, Siti Aekbal Salleh   +3 more
doaj   +1 more source

Robust Estimation of L₁-Modal Regression Under Functional Single-Index Models for Practical Applications

Mathematics
We propose a robust procedure to estimate the conditional mode of a univariate outcome O given a Hilbertian explanatory variable I, under the assumption that (O,I) follow a single-index structure.
Fatimah A. Almulhim, Mohammed B. Alamari, Salim Bouzebda, Zoulikha Kaid, Ali Laksaci   +4 more
doaj   +1 more source

A family of partial-linear single-index models for analyzing complex environmental exposures with continuous, categorical, time-to-event, and longitudinal health outcomes. [PDF]

Environ Health, 2020
Wang Y, Wu Y, Jacobson MH, Lee M, Jin P, Trasande L, Liu M.   +6 more
europepmc   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Composite quantile regression for the single-index model [PDF]

, 2013
Quantile regression is in the focus of many estimation techniques and is an important tool in data analysis. When it comes to nonparametric specifications of the conditional quantile (or more generally tail) curve one faces, as in mean regression, a dimensionality problem. We propose a projection based single index model specification.
Yan Fan, Wolfgang Karl Härdle, Weining Wang, Lixing Zhu   +3 more
openaire   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source