Results 151 to 160 of about 16,585,517 (291)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Cost-sensitive single-index classification model

European Journal of Operational Research
Xunta de Galicia; ED431C-2024 ...
Jorge C.-Rella, Ricardo Cao, Juan Manuel Vilar   +2 more
openaire   +2 more sources

Performance metrics of the Dynamic Criticality Index models developed from the multi-institutional database applied to the single-site test dataset (A) and the single-site Dynamic Criticality Index models applied to the single-site test dataset (B).

Performance metrics of the Dynamic Criticality Index models developed from the multi-institutional database applied to the single-site test dataset (A) and the single-site Dynamic Criticality Index models applied to the single-site test dataset (B).
Eduardo Trujillo-Rivera (14201036), Hiroki Morizono (6167360), James M. Chamberlain (5822240), Murray M. Pollack (5093639), Anita K. Patel (17134546)   +4 more
core   +1 more source

Predictive accuracy of comorbidity index models in assessing mortality risk among hemodialysis patients: A comprehensive single‐center observational cohort study

Aging Medicine
Objectives Comorbidity prediction models have been demonstrated to offer more comprehensive and accurate predictions of death risk compared to single indices.
Yanna Yu, Fen Li, Zhan Wang, Zhibin Ni, Shu Zhang, Weihong Zhao, Xiaohua Pei   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Predicting spring maize yield using UAV remote sensing

Guan'gai paishui xuebao
【Objective】Predicting potential crop yield is critical not only to policy making but also to improving agricultural management to safeguard food production.
MA Shijiao, FANG Chengtai, ZHAO Jinghua, LIU Feng, YANG Tingrui, YUAN Ruxin   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Leverage Sampling for Single-Index Models

, 2021
In this thesis, a generalized leverage-based sub-sampling method for single-index models is proposed. The approach gives more efficient estimators than random sub-samples of the same size.
Almutairi, Basmah
core  

Large-sample estimation and inference in multivariate single-index models. [PDF]

J Multivar Anal, 2019
Wu J, Peng H, Tu W.
europepmc   +1 more source