Results 121 to 130 of about 1,000,379 (258)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Fine-scale predictive modeling of Aedes mosquito abundance and dengue risk indicators using machine learning algorithms with microclimatic variables

Scientific Reports
Effective prediction of Aedes mosquito abundance and dengue risk indicators such as the Aedes Index (AI) and Dengue Positive Trap Index (DPTI) is essential for early intervention and targeted vector control.
Nazri Che Dom, Nur Athen Mohd Hardy Abdullah, Rahmat Dapari, Siti Aekbal Salleh   +3 more
doaj   +1 more source

Robust Estimation of L₁-Modal Regression Under Functional Single-Index Models for Practical Applications

Mathematics
We propose a robust procedure to estimate the conditional mode of a univariate outcome O given a Hilbertian explanatory variable I, under the assumption that (O,I) follow a single-index structure.
Fatimah A. Almulhim, Mohammed B. Alamari, Salim Bouzebda, Zoulikha Kaid, Ali Laksaci   +4 more
doaj   +1 more source

A family of partial-linear single-index models for analyzing complex environmental exposures with continuous, categorical, time-to-event, and longitudinal health outcomes. [PDF]

Environ Health, 2020
Wang Y, Wu Y, Jacobson MH, Lee M, Jin P, Trasande L, Liu M.   +6 more
europepmc   +1 more source

Composite quantile regression for the single-index model [PDF]

, 2013
Quantile regression is in the focus of many estimation techniques and is an important tool in data analysis. When it comes to nonparametric specifications of the conditional quantile (or more generally tail) curve one faces, as in mean regression, a dimensionality problem. We propose a projection based single index model specification.
Yan Fan, Wolfgang Karl Härdle, Weining Wang, Lixing Zhu   +3 more
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Robustness of Single Index Models in Crop Markets: A Multiple Index Model Test: Reply

Journal of Agricultural and Resource Economics, 1993
Steven C. Blank
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source