Results 121 to 130 of about 16,585,517 (291)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Longitudinal image-based prediction of surgical intervention in infants with hydronephrosis using deep learning: Is a single ultrasound enough?

PLOS Digital Health
The potential of deep learning to predict renal obstruction using kidney ultrasound images has been demonstrated. However, these image-based classifiers have incorporated information using only single-visit ultrasounds.
Adree Khondker, Stanley Bryan Z Hua, Jethro C C Kwong, Kunj Sheth, Daniel Alvarez, Kyla N Velaer, John Weaver, Alice Xiang, Gregory E Tasian, Armando J Lorenzo, Anna Goldenberg, Mandy Rickard, Lauren Erdman   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Generalized single-index models

, 2009
Generalized single-index models are natural extensions of linear models and circumvent the so-called curse of dimensionality. They are becoming increasingly popular in many scientific fields including biostatistics, medicine, economics and finan- cial econometrics.
Cui, Xia, Härdle, Wolfgang Karl, Zhu, Lixing   +2 more
openaire   +1 more source

A Sequential Approach to the Biodynamic Modeling of a Human Finger

Shock and Vibration, 2017
In an effort to understand the vibration-induced injuries incurred by manual workers, mechanical models are developed and used to predict the biodynamic responses of human body parts that are exposed to vibration.
Luka Knez, Janko Slavič, Miha Boltežar
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Learning Single Index Models with Diffusion Priors

CoRR
ICML ...
Anqi Tang, Youming Chen, Shuchen Xue, Zhaoqiang Liu   +3 more
openaire   +4 more sources

MODELING OF EXTRUSION PROCESS USING RESPONSE SURFACE METHODOLOGY AND ARTIFICIAL NEURAL NETWORKS [PDF]

Journal of Engineering Science and Technology, 2006
Artificial neural networks are a powerful tool for modeling of extrusion processing of food materials. Wheat flour and wheat– black soybean blend (95:5) were extruded in a single screw Brabender extruder with varying temperature (120 and 140 oC), dry ...
NEELAM SHIHANI, B. K. KUMBHAR, MANOJ KULSHRESHTHA   +2 more
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source