Results 71 to 80 of about 1,476,983 (297)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
MathematicsComplex diseases such as type 2 diabetes are influenced by both environmental and genetic risk factors, leading to a growing interest in identifying gene–environment (G × E) interactions.
Shunjie Guan, Xu Liu, Yuehua Cui
doaj +1 more source
Non-Standard Hierarchies of the Runnings of the Spectral Index in Inflation
Universe, 2017 Recent analyses of cosmic microwave background surveys have revealed hints that there may be a non-trivial running of the running of the spectral index.
Chris Longden
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Estimation for Single-index and Partially Linear Single-index Nonstationary Time Series Models
, 2014 Estimation in two classes of popular models, single-index models and partially linear single-index models, is studied in this paper. Such models feature nonstationarity.
Chaohua Dong (3217545) +2 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Semiparametric Estimation of Single-Index Transition Intensities [PDF]
This research develops semiparametric kernel-based estimators of state-specific conditional transition intensities, h(y|x), for duration models with right-censoring and/or multiple destinations (competing risks).
Tue Gorgens
core +2 more sources
Journal of Petroleum Exploration and Production Technology, 2020 The main objective of this paper is to understand the impact of the fractal characteristics of fractured reservoirs on their pressure behavior, flow rate decline, and productivity index.
Salam Al-Rbeawi
doaj +1 more source
Generalized single-index models: The EFM approach [PDF]
Generalized single-index models are natural extensions of linear models and circumvent the so-called curse of dimensionality. They are becoming increasingly popular in many scientific fields including biostatistics, medicine, economics and finan- cial ...
Xia Cui +2 more
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