Results 91 to 100 of about 991,751 (258)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

SILVar: Single Index Latent Variable Models

IEEE Transactions on Signal Processing, 2018
Print ISSN: 1053-587X Online ISSN: 1941-0476, IEEE Transactions on Signal Processing, online March 21 ...
Jonathan Mei, José M. F. Moura
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Longitudinal image-based prediction of surgical intervention in infants with hydronephrosis using deep learning: Is a single ultrasound enough?

PLOS Digital Health
The potential of deep learning to predict renal obstruction using kidney ultrasound images has been demonstrated. However, these image-based classifiers have incorporated information using only single-visit ultrasounds.
Adree Khondker, Stanley Bryan Z Hua, Jethro C C Kwong, Kunj Sheth, Daniel Alvarez, Kyla N Velaer, John Weaver, Alice Xiang, Gregory E Tasian, Armando J Lorenzo, Anna Goldenberg, Mandy Rickard, Lauren Erdman   +12 more
doaj   +1 more source

A Sequential Approach to the Biodynamic Modeling of a Human Finger

Shock and Vibration, 2017
In an effort to understand the vibration-induced injuries incurred by manual workers, mechanical models are developed and used to predict the biodynamic responses of human body parts that are exposed to vibration.
Luka Knez, Janko Slavič, Miha Boltežar
doaj   +1 more source

Learning Single Index Models in High Dimensions

CoRR, 2015
16 pages, 2 figures, 1 ...
Ravi Ganti, Nikhil Rao 0001, Rebecca M. Willett, Robert D. Nowak   +3 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

MODELING OF EXTRUSION PROCESS USING RESPONSE SURFACE METHODOLOGY AND ARTIFICIAL NEURAL NETWORKS [PDF]

Journal of Engineering Science and Technology, 2006
Artificial neural networks are a powerful tool for modeling of extrusion processing of food materials. Wheat flour and wheat– black soybean blend (95:5) were extruded in a single screw Brabender extruder with varying temperature (120 and 140 oC), dry ...
NEELAM SHIHANI, B. K. KUMBHAR, MANOJ KULSHRESHTHA   +2 more
doaj  

Genomic Prediction Accounting for Genotype by Environment Interaction Offers an Effective Framework for Breeding Simultaneously for Adaptation to an Abiotic Stress and Performance Under Normal Cropping Conditions in Rice

G3: Genes, Genomes, Genetics, 2018
Developing rice varieties adapted to alternate wetting and drying water management is crucial for the sustainability of irrigated rice cropping systems. Here we report the first study exploring the feasibility of breeding rice for adaptation to alternate
Manel Ben Hassen, Jérôme Bartholomé, Giampiero Valè, Tuong-Vi Cao, Nourollah Ahmadi   +4 more
doaj   +1 more source