Results 271 to 280 of about 1,193,038 (282)
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Annual Review of Analytical Chemistry, 2010
The ability to detect single molecules of DNA or RNA has led to an extremely rich area of exploration of the single most important biomolecule in nature. In cases in which the nucleic acid molecules are tethered to a solid support, confined to a channel, or simply allowed to diffuse into a detection volume, novel techniques have been developed to ...
J William, Efcavitch, John F, Thompson
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The ability to detect single molecules of DNA or RNA has led to an extremely rich area of exploration of the single most important biomolecule in nature. In cases in which the nucleic acid molecules are tethered to a solid support, confined to a channel, or simply allowed to diffuse into a detection volume, novel techniques have been developed to ...
J William, Efcavitch, John F, Thompson
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SINGLE-MOLECULE ELECTRICAL JUNCTIONS
Annual Review of Physical Chemistry, 2006▪ Abstract  The objective of this review is to describe current experimental research of single-molecule electrical junctions in the context of various theoretical frameworks, with emphasis on the application of single-electron transistor theory to molecular junctions. Molecule quantum dots are at least an order of magnitude smaller than semiconductor
Yoram, Selzer, David L, Allara
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Multiplexed single molecule immunoassays
Lab on a Chip, 2013We have developed a method that enables the multiplexed detection of proteins based on counting single molecules. Paramagnetic beads were labeled with fluorescent dyes to create optically distinct subpopulations of beads, and antibodies to specific proteins were then immobilized to individual subpopulations.
David M, Rissin +11 more
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A Single-Molecule Potentiometer
Nano Letters, 2011Controlling electron transport through a single-molecule device is key to the realization of nanoscale electronic components. A design requirement for single molecule electrical devices is that the molecule must be both structurally and electrically connected to the metallic electrodes.
Jeffrey S, Meisner +5 more
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2011
We rarely get the opportunity to see how individual molecules behave. Mostly what we see are the average effects of large numbers of molecules. Molecular structures determined by crystallographic or NMR methods are time- and number-averages of a large population of molecules.
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We rarely get the opportunity to see how individual molecules behave. Mostly what we see are the average effects of large numbers of molecules. Molecular structures determined by crystallographic or NMR methods are time- and number-averages of a large population of molecules.
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Single molecule: Single molecules meet systems biology.
Nature methods, 2010Application of single-molecule methods to assay genome-wide mRNA and protein levels in single bacteria provides a systems-level view of their relationship.
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