Results 121 to 130 of about 24,160 (252)

Exceptional CO2 Hydrogenation to Gasoline Enabled by GaZrOx/Ga‐ZSM‐5 Tandem Catalyst

open access: yesAdvanced Science, EarlyView.
A GaZrOx/Ga‐ZSM‐5 tandem catalyst achieves 17.2% CO2 conversion with 83.2% C5+ selectivity and >400 h stability relies on optimized O‐vacancies and Ga‐H coverage for CO2 hydrogenation. ABSTRACT CO2 hydrogenation to gasoline offers a promising route for addressing energy challenges and enabling the effective utilization of carbon resources. However, the
Wenhui Li   +5 more
wiley   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng   +7 more
wiley   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang   +10 more
wiley   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

open access: yesAdvanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang   +13 more
wiley   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

open access: yesAdvanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim   +2 more
wiley   +1 more source

Single-Inhaler Triple Therapy in Primary Care Across Europe: Expert Panel Consensus on the Consequences of Payer-Driven Access Rules and Call to Action

open access: yesInternational Journal of COPD
Fabiano Di Marco,1 Orjola Shahaj,2 Arschang Valipour,3 Bertrand Legrand,4 Claudio Jommi,5 Claudio Micheletto,6 Claus Franz Vogelmeier,7 Daryl Freeman,8 Janwillem WH Kocks,9 Luis Alves,10 Myriam Calle Rubio,11 Rudi Peché,12 Susanna Palkonen Snr,13 Tonya ...
Di Marco F   +14 more
doaj  

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