Results 101 to 110 of about 2,892,749 (302)
MATEC Web of Conferences, 2016 Turbulent droplet-laden flow downstream of a sudden pipe expansion is numerically studied using Eulerian two-fluid model. The model is used to investigate the effect of droplet evaporation on the particle dispersion and on the gas phase turbulence ...
Pakhomov Maksim, Terekhov Viktor
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Investigation of Adiabatic Refrigerant Pressure Drop and Flow Visualization in Flat Plate Evaporators [PDF]
, 2001 Adiabatic pressure drop and flow visualization in chevron plate, 1:1 aspect ratio bumpy plate, and 2:1 aspect ratio bumpy plate heat exchangers were investigated for vertical upward flow with R134a.
Chato, J.C., Jassim, E.W., Newell, T.A.
core
Large-eddy simulations of turbulent flow for grid-to-rod fretting in nuclear reactors
, 2013 The grid-to-rod fretting (GTRF) problem in pressurized water reactors is a flow-induced vibration problem that results in wear and failure of the fuel rods in nuclear assemblies.
Bakosi, J. +4 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Droplets in homogeneous shear turbulence
, 2019 We simulate the flow of two immiscible and incompressible fluids separated by an interface in a homogeneous turbulent shear flow at a shear Reynolds number equal to 15200.
Brandt, Luca +4 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Research Progress of Microchannel Heat Sink Structures Based on Single-Phase Flow
Zhileng xuebaoMicrochannel cooling, with its high heat transfer efficiency, low thermal resistance, and light weight advantages, is one of the most effective technologies for solving the problem of heat dissipation with high heat flux; however, it faces the issue of ...
Zhao Jie, Cui Xiaoyu
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source