Results 111 to 120 of about 39,032 (308)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Novel Shunt Zigzag Double-Tap Low-Harmonic Multi-Pulse Rectifier Based on a Three-Stage Power Electronic Phase-Shifting Transformer

Sensors
To solve the problem of the large size of traditional industrial frequency phase-shift transformers and the harmonic distortion of multi-pulse wave rectifier systems, this paper proposes a three-stage shunt zigzag power electronic phase-shift transformer
Xiuqing Mu, Xiaoqiang Chen, Qianxiao Liu, Ying Wang, Tun Bai, Leijiao Ge, Xiping Ma   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A Topology-Based Model for Two-Winding, Shell-Type, Single Phase Transformer Inter-Turn Faults

, 2014
This thesis developed a topology-based model for two-winding, shell-type, single-phase transformer inter-turn faults. The principle of duality between the electric and magnetic equivalent circuits is concisely explained. The magnetic equivalent circuit
Zhuang, Liman
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Impacts of New Suggested Ferroresonance Limiter on the Stability Domain of Ferroresonance Modes in Power Transformers Considering Metal Oxide Surge Arrester Effect

Iranian Journal of Electrical and Electronic Engineering, 2011
this work studies the effect of neutral earth resistance on the controlling ferroresonance oscillation in the power transformer including MOV surge arrester.
H. Radmanesh, M. Rostami
doaj  

Analysis and Rapid Calculation of Magnetic Thermal Coupling Characteristics of Large Power Transformers

Elektronika ir Elektrotechnika
Conventional single-phase nuclear main transformers are susceptible to certain risks such as an increase in high local temperature in the windings, high leakage fields, and high short-circuit forces. Moreover, these transformers are too costly to use. In
Hong Liu, Guodong Li, Xuan Wang, Hua Yu, Bin Li, Tong Song, Changjiang Na, Haibo Wang   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Retificador trifásico isolado com fator de potência unitário baseado no transformador scott [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Engenharia Elétrica.O trabalho proposto nesta dissertação tem como finalidade analisar e implementar o retificador trifásico isolado com ...
Miller, Stephanie Katherine Teixeira
core