Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
FUSION-AD: interpretable AI framework for risk assessment and subgroup discovery in Alzheimer's disease. [PDF]
Iqbal A, Arif S, Husnain G, Ayouni S.
europepmc +1 more source
Delta & star connection of single phase transformer
種別 ...
openaire
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Clinician-Centered Evaluation Framework for Explainable AI Heatmaps in OCT-Based Retinal Disease Classification. [PDF]
Maliagkani E +4 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
An Efficient Wi-Fi Sensing Method for Robotic Arm Motion Recognition. [PDF]
Zhuo J +5 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
A Two-Stage Deep Learning Method for Non-Invasive Sow Body Temperature Prediction Fusing Thermal Imaging and Environmental Parameters. [PDF]
Xu S, Qin Z, Huang Q, Tan C, Xu X, Li X.
europepmc +1 more source
Economical distribution of losses in single phase transformers
種別:卒業論文 改姓 ...
openaire

