Results 41 to 50 of about 89,571 (244)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

A Control Method for Static VAR Compensator Based On Modular Multilevel Inverter [PDF]

open access: yes, 2009
Multilevel inverters are promised to provide a better performance in high power applications such as static VAR compensators. The proposed modular inverter has advantages compared to the conventional technologies.
Dahono, Pekik
core  

A Generalized Index for Static Voltage Stability of Unbalanced Polyphase Power Systems including Th\'evenin Equivalents and Polynomial Models [PDF]

open access: yes, 2019
This paper proposes a Voltage Stability Index (VSI) suitable for unbalanced polyphase power systems. To this end, the grid is represented by a polyphase multiport network model (i.e., compound hybrid parameters), and the aggregate behavior of the devices
Kettner, Andreas Martin, Paolone, Mario
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Power quality and electromagnetic compatibility: special report, session 2 [PDF]

open access: yes, 2015
The scope of Session 2 (S2) has been defined as follows by the Session Advisory Group and the Technical Committee: Power Quality (PQ), with the more general concept of electromagnetic compatibility (EMC) and with some related safety problems in ...
Desmet, Jan   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Temperature characterisation of an optically-interrogated Rogowski coil [PDF]

open access: yes, 2014
An investigation into the performance of an optically-interrogated Rogowski coil over temperatures up to 80 °C is presented. Preliminary thermal tests reveal that the sensor response is temperature-dependent and the measurement errors are increased at ...
Fusiek, Grzegorz   +2 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Technical and vocational skills (TVS): a means of preventing violence among youth in Nigeria [PDF]

open access: yes, 2017
Technical and vocational skills are an important tool for reducing violence among youth, especially in Nigeria, who face security challenges due to different kinds of violence.
Ibrahim, Mohammed   +1 more
core  

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