Results 61 to 70 of about 9,954 (268)

Investigation оf Microprocessor Differential Protection оf Power Reducing Transformer

Наука и техника, 2014
The paper presents investigations on functioning of a differential protection of 110 kV reducing transformer  with internal faults using computer simulation.
F. A. Romaniuk, M. S. Loman
doaj  

Low-Frequency Transient Model of Single-Phase Four-Limb Converter Transformer Considering the Nonlinear Excitation Characteristics of the Iron Core

Applied Sciences
Transformer modeling is a crucial method for analyzing transient phenomena such as inrush currents. The primary characteristic of a transformer transient model is its ability to reflect how the transformer’s structure and material properties influence ...
Xichen Pei, Lan Xiong, Zhanlong Zhang, Zijian Dong, Yu Yang, Jiatai Gao, Tao Feng   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Development of an Electromagnetic‐Thermal Circuit Model for Single‐Phase Three‐Limb Transformers

High Voltage
Analysing the heat states of transformers under DC bias requires careful consideration of their own structural and material characteristics. Although the 3D finite element method (FEM) is a reliable way of simulating all the details of transformers, it ...
Yidan Hu, Jiawen Yu, Zhaoyu Zhang, Xuanrui Zhang, Junhao Li, Roberto Ottoboni   +5 more
doaj   +1 more source

A Direct Power Feeding System for AC Railway Networks Using Modular Multilevel Converter [PDF]

International Journal of Railway Research, 2018
Traditional railway power supply systems impose substantial power quality problems (PQ) on the utility network, such as unbalance, harmonics and a large amount of reactive power. This paper proposes a topology based on three-phase to single-phase modular
Hamed Jafari Kaleybar, Hossein Madadi Kojabadi, Seyed Saeed Fazel, Federica Foiadelli, Morris Brenna   +4 more
doaj  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Buildup of Fault Protection for High-Current Single-Phase Transformers in Ore Furnaces

Energies
High-power ore furnaces mainly use single-phase transformers supplied by phase-to-phase voltage with the secondary winding made in the form of four to eight isolated splits and a high-voltage busbar assembly made of the same number of pairs of tube buses.
Dilara Rakhimberdinova, Aleksandr Novozhilov, Evgeniy Kolesnikov, Vladimir Goryunov, Timofey Novozhilov   +4 more
doaj   +1 more source