Results 171 to 180 of about 7,610,196 (308)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Safety and Efficacy of Single-Stage Synchronous Bilateral VATS Talc Poudrage for Malignant Pleural Effusion. [PDF]

Cancers (Basel)
Mazzella A, Degiovanni S, Mariani E, Cerretani G, Bertolaccini L, Casiraghi M, Sedda G, Lo Iacono G, Spaggiari L.   +8 more
europepmc   +1 more source

Evaluation of a Modified Single-Stage Continuous Curvilinear Capsulorhexis Technique Using 18-Gauge Needle Decompression in Intumescent Cataracts

Trung Kien Hoang,1,2 Huynh Phuc Nguyen,1,3 Van Nam Phan2 1Department of Ophthalmology, Saigon Vinh Eye Hospital, Vinh City, Vietnam; 2Department of Ophthalmology, Hue University of Medicine and Pharmacy, Hue City, Vietnam; 3Department of Ophthalmology ...
Phan VN, Nguyen HP, Hoang TK
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Novel single stage multipath 8 × 8 interconnection network/switching element (SSMIN/E) architecture. [PDF]

Sci Rep
Gupta S, Bala M, Jondhale SR, Jondhale AS, Sharma G.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Midfoot Skeletal Tuberculosis Managed With Single-Stage Tarsometatarsal and Naviculocuneiform Arthrodesis and Antitubercular Therapy. [PDF]

Foot Ankle Orthop
Tolin JC, Jones C, Jain A, Manway J, Arbulu R.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Single-Stage Paramedian Forehead Flap

Actas Dermo-Sifiliográficas (English Edition), 2017
A, Martinez-Lopez, I, Perez-Lopez, E, Garcia-Dura, J, Tercedor-Sanchez   +3 more
openaire   +2 more sources

Upper Sternal Cleft Associated With Congenital Cardiac Defect: Single Stage Surgical Correction. [PDF]

Interdiscip Cardiovasc Thorac Surg
Omanik P, Valentik P, Nosal M, Beder I.
europepmc   +1 more source