Results 121 to 130 of about 3,562,031 (294)
Coding against Spreading Gain Optimization of Nonbinary BCH Coded CDMA System
, 2005 The joint analytical optimisation of the spreading gain and coding gain of nonbinary BCH coded CDMA communication systems is considered in both single-cell and multi-cell scenarios.
Hanzo, L., Wei, H.
core
Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]
, 1988 We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Genetic analysis by single cell typing
Animal Biotechnology, 1994 Abstract The analysis of DNA sequences in a single cell using the polymerase chain reaction (PCR) is now possible. This has led to the development of a new method for constructing genetic maps based on the analysis of single sperm. The method is partially automated and is capable of constructing high resolution genetic maps of DNA polymorphisms.
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Single-cell type annotation with deep learning in 265 cell types for humans
Bioinformatics AdvancesAbstract Motivation Annotating cell types is a challenging yet essential task in analyzing single-cell RNA sequencing data. However, due to the lack of a gold standard, it is difficult to evaluate the algorithms fairly and an overfitting algorithm may be favored in benchmarks.
Sherry Dong, Kaiwen Deng, Xiuzhen Huang
openaire +2 more sources
Missing cell types in single-cell references impact deconvolution of bulk data but are detectable
Genome BiologyBackground Advancements in RNA sequencing have expanded our ability to study gene expression profiles of biological samples in bulk tissue and single cells.
Adriana Ivich +6 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
JCI Insight, 2022 Clinical outcomes in colorectal cancer (CRC) correlate with T cell infiltrates, but the specific contributions of heterogenous T cell types remain unclear.
Kazuya Masuda +20 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source