Results 41 to 50 of about 3,543,075 (195)
Molecular recording of mammalian embryogenesis. [PDF]
, 2019 Ontogeny describes the emergence of complex multicellular organisms from single totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate relationship between self-renewal and differentiation, variation in progenitor
Adamson, Britt +13 more
core +2 more sources
BMC Bioinformatics, 2023 Background Quantifying cell-type abundance in bulk tissue RNA-sequencing enables researchers to better understand complex systems. Newer deconvolution methodologies, such as MuSiC, use cell-type signatures derived from single-cell RNA-sequencing (scRNA ...
Nicholas K. O’Neill +7 more
doaj +1 more source
Reconstruction of Cell-type-Specific Interactomes at Single-Cell Resolution [PDF]
Cell Systems, 2019 The human interactome is instrumental in the systems-level study of the cell and the contextualization of disease-associated gene perturbations. However, reference organismal interactomes do not capture the cell-type-specific context in which proteins and modules preferentially act. Here, we introduce SCINET, a computational framework that reconstructs
Mohammadi, Shahin +2 more
openaire +3 more sources
A single–cell type transcriptomics map of human tissues [PDF]
Science Advances, 2021 Single-cell RNA analysis has been integrated with spatial protein profiling to create a single–cell type map of human tissues.
Max Karlsson +24 more
openaire +7 more sources
Defining cell types and states with single-cell genomics [PDF]
Genome Research, 2015 A revolution in cellular measurement technology is under way: For the first time, we have the ability to monitor global gene regulation in thousands of individual cells in a single experiment. Such experiments will allow us to discover new cell types and states and trace their developmental origins.
openaire +2 more sources
Collective cell durotaxis emerges from long-range intercellular force transmission [PDF]
, 2016 The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that exhibited durotaxis even if isolated constituent cells did not. This
Conte, V +10 more
core +2 more sources
scPred: Cell type prediction at single-cell resolution [PDF]
, 2018 AbstractSingle-cell RNA sequencing has enabled the characterization of highly specific cell types in many human tissues, as well as both primary and stem cell-derived cell lines. An important facet of these studies is the ability to identify the transcriptional signatures that define a cell type or state.
Alquicira-Hernández, José +4 more
openaire +1 more source
MARS: discovering novel cell types across heterogeneous single-cell experiments [PDF]
Nature Methods, 2020 Although tremendous effort has been put into cell-type annotation, identification of previously uncharacterized cell types in heterogeneous single-cell RNA-seq data remains a challenge. Here we present MARS, a meta-learning approach for identifying and annotating known as well as new cell types.
Maria Brbić +6 more
openaire +2 more sources
, 2003 The embryo is a remarkable self-assembly machine. From a single cell, the fertilized egg, arises all of the differentiated cell types of the body. Embryos unfold in an elegantly choreographed manner that we strive to understand by observing the process ...
Bronner-Fraser, Marianne
core +1 more source
Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. [PDF]
, 2018 Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the levels of multiple cell surface or intracellular
Chang, Howard Y +8 more
core +2 more sources