Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
core +2 more sources
Computational and Structural Biotechnology JournalSingle-cell RNA sequencing (scRNA-seq) is currently an important technology for identifying cell types and studying diseases at the genetic level. Identifying rare cell types is biologically important as one of the downstream data analyses of single-cell
Shudong Wang +8 more
doaj +1 more source
Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology. [PDF]
, 2019 High costs and technical limitations of cell sorting and single-cell techniques currently restrict the collection of large-scale, cell-type-specific DNA methylation data.
Barcellos, Lisa F +8 more
core
DART-ID increases single-cell proteome coverage. [PDF]
, 2019 Analysis by liquid chromatography and tandem mass spectrometry (LC-MS/MS) can identify and quantify thousands of proteins in microgram-level samples, such as those comprised of thousands of cells.
Chen, Albert Tian +2 more
core +3 more sources
ScLSTM: single-cell type detection by siamese recurrent network and hierarchical clustering
BMC Bioinformatics, 2023 Motivation Categorizing cells into distinct types can shed light on biological tissue functions and interactions, and uncover specific mechanisms under pathological conditions.
Hanjing Jiang +3 more
doaj +1 more source
Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. [PDF]
, 2019 Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific gene networks results in birth defects, which affect 5% of live births.
de Soysa, T Yvanka +9 more
core
Cross-Species Analysis of Single-Cell Transcriptomic Data
Frontiers in Cell and Developmental Biology, 2019 The ability to profile hundreds of thousands to millions of single cells using scRNA-sequencing has revolutionized the fields of cell and developmental biology, providing incredible insights into the diversity of forms and functions of cell types across ...
Maxwell E. R. Shafer +1 more
doaj +1 more source
Single-cell transcriptome analyses reveal microglia types associated with proliferative retinopathy
JCI Insight, 2022 Pathological angiogenesis is a major cause of irreversible blindness in individuals of all age groups with proliferative retinopathy (PR). Mononuclear phagocytes (MPs) within neovascular areas contribute to aberrant retinal angiogenesis.
Zhiping Liu +14 more
doaj +1 more source
scMD: cell type deconvolution using single-cell DNA methylation references
, 2023 AbstractThe proliferation of single-cell RNA sequencing data has led to the widespread use of cellular deconvolution, aiding the extraction of cell type-specific information from extensive bulk data. However, those advances have been mostly limited to transcriptomic data. With recent development in single-cell DNA methylation (scDNAm), new avenues have
Manqi Cai +3 more
openaire +2 more sources
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
BMC Biology, 2018 Background Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the epithelial subsets of the gastrointestinal tract.
Benjamin E. Mead +17 more
doaj +1 more source