Results 121 to 130 of about 1,835,423 (352)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Crystal Growth and Ferroelectric Properties of Thiourea Picrate Single Crystal

open access: yesФізика і хімія твердого тіла
Ferroelectric hysteresis (P-E) loop study strongly confirmed that Thiourea Picrate (TUP) crystal is a new lead free, prolific ferroelectric material and good switching behavior of the polarization.
A. Shanthi, S.C. Vella Durai
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Single-crystal perovskite devices [PDF]

open access: yesScience Bulletin, 2021
Yuelong, Li, Liming, Ding
openaire   +2 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

LOW CYCLE FATIGUE LIFE PREDICTION METHOD FOR SINGLE CRYSTAL NICKEL-BASE SUPERALLOYS AT HIGH TEMPERATURE

open access: yesJixie qiangdu, 2015
A low cycle fatigue life prediction method for single crystal nickel-base superalloys at high temperature is presented,and the method can consider the effect of average stress,strain ratio and crystal orientation on fatigue life.Firstly,a fatigue life ...
CHEN Hong, JIANG HongDe
doaj  

Controlling crystal orientation of Ni-based single crystal superalloy by inclined seeding method

open access: yesCailiao gongcheng
An inclined seeding method for Ni-based single crystal superalloy with a specific orientation is presented. The evolution of solidification microstructure and its mechanism are studied during the preparation of single crystals by this method through ...
YANG Shuai   +6 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao   +10 more
wiley   +1 more source

Experimental on friction polishing of single crystal diamond with iron-based and nickel-based alloy materials

open access: yesJin'gangshi yu moliao moju gongcheng
ObjectivesSingle crystal diamond is widely used in the field of diamond optical windows due to its superior chemical stability, good heat resistance, and low atomic number.
Simeng ZHU, Fanghong SUN, Ning YANG
doaj   +1 more source

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