Results 61 to 70 of about 1,835,423 (352)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K⁺ Metal-Organic Framework in Various Solvents

Crystals, 2020
Cyclodextrin (CD) has been used to prepare biocompatible and nontoxic metal-organic frameworks (MOFs) suitable for biomedical applications as drug carriers.
Kristīne Krūkle-Bērziņa, Sergey Belyakov, Anatoly Mishnev, Kirill Shubin   +3 more
doaj   +1 more source

Floating zone process for drawing small diameter fibers of refractory materials [PDF]

, 1972
New process produces controlled purity, very high strength, single crystal fibers of materials with melting points to 4000 C. Process has been used to make single crystal fibers of highly refractory ceramics such as aluminum oxide, titanium carbide and ...
Haggerty, J., Menashi, W. P., Wenckus, J. F., Westfall, L. J.   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Raman Spectroscopic and SEM Analysis of Sodium-Zippeite [PDF]

, 2007
Raman at 298 and 77 K and infrared spectra of two samples of sodium-zippeite were studied and interpreted. U-O bond lengths in uranyl were calculated and compared with those inferred from the X-ray single crystal structure data of a synthetic sodium ...
Anderson, Bartlett, Burns, Burns, Burns, Burns, Cejka, Cejka, Elton, Finch, Frondel, Frondel, Frondel, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Frost, Gaines, Haacke, Hawthorne, Hawthorne, Hawthorne, Hawthorne, Hoekstra, Libowitzky, McCollam, Meisser, O'Brien, Ondrus, Paulis, Sejkora, Serezhkin, Volod'ko   +43 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Redetermination of the crystal structures of rare-earth trirhodium diboride RERh3B2 (RE = Pr, Nd and Sm) from single-crystal X-ray data

Acta Crystallographica Section E: Crystallographic Communications, 2022
The crystal structures of the rare-earth (RE) trirhodium diborides praseodymium trirhodium diboride, PrRh3B2, neodymium trirhodium diboride, NdRh3B2, and samarium trirhodium diboride, SmRh3B2, were refined on the basis of single-crystal X-ray diffraction
Makoto Tokuda, Kunio Yubuta, Toetsu Shishido, Kazumasa Sugiyama   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Electrical power dissipation in carbon nanotubes on single crystal quartz and amorphous SiO2

, 2011
Heat dissipation in electrically biased semiconducting carbon nanotubes (CNTs) on single crystal quartz and amorphous SiO2 is examined with temperature profiles obtained by spatially resolved Raman spectroscopy.
Liao, Albert, Pop, Eric, Shim, Moonsub, Tsai, Cheng-Lin   +3 more
core   +1 more source