Results 121 to 130 of about 7,977,529 (305)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Factors influencing of TAM recovery after replantation of severed finger

Huli yanjiu, 2020
ObjectiveTo analyze influencing factors of total active motion（TAM）recovery of finger after replantation of severed fingers.MethodsTotally 250 patients who's fingers were successfully replanted in our hospital from December 2015 to December 2017，were ...
ZHU Linyi, FU Yuhong, MAO Leiyin, GAO Liting   +3 more
doaj  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Do Jumps Matter? Forecasting Multivariate Realized Volatility allowing for Common Jumps [PDF]

Realized volatility of stock returns is often decomposed into two distinct components that are attributed to continuous price variation and jumps. This paper proposes a tobit multivariate factor model for the jumps coupled with a standard multivariate ...
Farshid Vahid, Heather M. Anderson, Yin Liao   +2 more
core  

Single-cell transcriptome analysis reveals characteristic transcription factors in polydactyly.

European review for medical and pharmacological sciences
The study aims to provide guidance on the identification of multiple-digit malformations as potential biomarkers and therapeutic targets.Single-cell RNA sequencing (scRNA-seq) data of four multiple-finger malformation samples were downloaded from the GEO public database.
Fu, D.-S., Muheremu, A.
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Analysis on Oriented Torque of Straddle-type Monorail Vehicle

机车电传动, 2014
With theoretical analysis of straddle-type monorail vehicle curve-through performance, conception of ’Oriented torque’ withits evaluation criterion used to rate the oriented performance was presented. With the single factor sensitivity analysis and ADAMS
DU Zi-xue, LIANG Zhi-hua, WEN Xiao-xia
doaj  

Single-Factor Polynomial Component Analysis

, 2013
Polynomial component and factor analysis are defined. Algorithms, based on multidimensional array approximation methods, to fit a model with a single common factor to observed multivariate cumulants are described and applied to a psychometric example. Software in R is included.
openaire   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source