Results 31 to 40 of about 3,226,624 (266)

Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

eLife, 2019
To fully exploit the potential of single-cell functional genomics in the study of development and disease, robust methods are needed to simplify the analysis of data across samples, time-points and individuals.
Min Jung, Daniel Wells, Jannette Rusch, Suhaira Ahmad, Jonathan Marchini, Simon R Myers, Donald F Conrad   +6 more
doaj   +1 more source

scANANSE gene regulatory network and motif analysis of single-cell clusters [version 2; peer review: 2 approved]

F1000Research, 2023
The recent development of single-cell techniques is essential to unravel complex biological systems. By measuring the transcriptome and the accessible genome on a single-cell level, cellular heterogeneity in a biological environment can be deciphered ...
Julian A. Arts, Siebren Frölich, Jos G.A. Smits, Huiqing Zhou, Joost H.A. Martens, Simon J. van Heeringen, Rebecca R. Snabel, Branco M.H. Heuts   +7 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Health‐Related Social Needs in Children With Sickle Cell Disease Are Associated With Worse Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks, Molly Sonenklar, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler   +5 more
wiley   +1 more source

Screening of renal clear cell carcinoma prognostic marker genes based on TCGA and GTEx chip data and construction of transcription factor-related regulatory networks

Heliyon, 2023
This study aimed to identify prognostic marker genes for renal clear cell carcinoma (RCCC) and construct a regulatory network of transcription factors and prognostic marker genes. Three hundred eighty-six genes were significantly differentially expressed
Wei Zhu, Lingfeng Wu, Wenhua Xie, Gaoyue Zhang, Yanqin Gu, Yansong Hou, Yi He   +6 more
doaj   +1 more source

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

Analysis of key elements affecting production and technical countermeasures to increase production of CBM fractured single horizontal wells: A case study of Zhengzhuang Block

Meitan kexue jishu
As the main technology of CBM development in the Qinshui CBM field, single-branch fractured horizontal wells have supported the breakthrough of 2 billion m3/year production of gas field.
Chen ZHANG, Meng HE, Yuhang XIAO, Zhong LIU, Sheng HAN, Xiuqin LU, Zihan WANG, Haoyu WU, Qianqian ZHANG   +8 more
doaj   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

Characteristics of groundwater system and assessment of groundwater vulnerability of the Tengchong volcano group in western Yunnan

Carsologica Sinica
The Tengchong volcanic group encompasses a vast area and exhibits a diverse range of eruption types. It is one of the youngest volcanic areas in China.
Yangyang WANG, Shengdong HUANG, Dong PAN, Guiren HUANG, Yu WANG, He CHANG, Yue PU   +6 more
doaj   +1 more source

Risk Factor Analysis of Single Motorcycle Accidents in Road Traffic

Applied Sciences
This research examines the risk factors that influence injury severity in individual motorcycle accidents, utilising a dataset of 5253 incidents. Five machine learning algorithms—multinomial logistic regression, classification trees, random forests ...
Edward Kozłowski, Mateusz Traczyński, Przemysław Skoczyński, Piotr Jaskowski, Radovan Madlenak   +4 more
doaj   +1 more source