Results 91 to 100 of about 2,855,386 (298)

Binary Choice Health State Valuation and Mode of Administration: Head-to-Head Comparison of Online and CAPI [PDF]

open access: yes, 2013
This article is made available open access through funding by the Medical Research Council. It is shared under a Creative Commons licence (http://creativecommons.org/licenses/by/3.0/).
Tsuchiya, Aki   +13 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The design of national health insurance : evaluation of options for Jamica [PDF]

open access: yes
This study presents findings from evaluating, ex ante, the options, implications and feasibility of a major health financing policy change from a largely tax-based to a principles.
Lalta, Stanley
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Evaluating the pediatric mental health care continuum at an American health system

open access: yes, 2023
OBJECTIVE: To describe trends in the pediatric mental health care continuum and identify potential gaps in care coordination. METHODS: We used electronic medical record data from October 2016 to September 2019 to characterize the prevalence of mental ...
Seiler, Kristian   +8 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The influence of system quality characteristics on health care providers’ performance: Empirical evidence from Malaysia

open access: yesJournal of Infection and Public Health, 2016
Summary: Background: The Ministry of Health Malaysia initiated the total hospital information system (THIS) as the first national electronic health record system for use in selected public hospitals across the country.
Mohd Idzwan Mohd Salleh   +2 more
doaj   +1 more source

Providing integrated health and social care for older persons in the United Kingdom [PDF]

open access: yes, 2003
This report provides an overview of the development of integrated health and social care provision for older people in the UK. It explore why integration is important, identifies the main impediments to effective integration, considers failed past ...
Billings, Jenny R.   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Changes in the Welfare Caseload and the Health of Low-educated Mothers [PDF]

open access: yes
Declines in the welfare caseload in the late 1990s brought significant change to the lives of many low-educated, single mothers. Many single mothers left welfare and entered the labor market and others re-arranged their lives in order to avoid going on ...
Elizabeth Tarlov, Robert Kaestner
core  

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