Results 171 to 180 of about 1,313,992 (262)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Artificial Intelligence-Enabled Serial Electrocardiograms for Prediction of All-Cause Mortality in Secondary Care Settings. [PDF]

JACC Adv
Tsaban G, Harari A, Shiloh A, Shamia D, Rokach L, Gordon M, Haim M, Katz G.   +7 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Development and Validation of a Nomogram Integrating Body Composition and Inflammatory Markers to Predict Concurrent Chemoradiotherapy Response in Locally Advanced Cervical Cancer. [PDF]

Cancer Manag Res
Liu L, Zhang Q, Liu L, Wu Z, Zhang X, Qiao J, Chen M.   +6 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Lung ultrasound B-lines, NT-proBNP, and left atrial volume Index for bedside characterization of preserved-ejection-fraction phenotype in acute heart failure: a single-center observational study. [PDF]

Front Cardiovasc Med
Peng B, Zhang Y.
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

SPISE Index (Single-Point Insulin Sensitivity Estimator): A Long-Term Predictor of Recurrence in Elderly Patients with Atrial Fibrillation After Radiofrequency Ablation. [PDF]

Clin Interv Aging
Wang Z, Qu Y, Wang H, Liu X.
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Gender-specific spKt/V thresholds associated with mortality in maintenance hemodialysis patients: a nationwide Korean cohort study. [PDF]

Sci Rep
Kim DH, Park HC, Cho A, Kim BY, Lee M, Kim GO, Kim J, Lee YK.   +7 more
europepmc   +1 more source