Results 251 to 260 of about 23,910,911 (290)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Prognostic value of changes in skeletal muscle index on serial computed tomography scans for overall survival in patients with advanced non-small cell lung cancer: a single-center retrospective study. [PDF]

J Thorac Dis
Zhou YY, Guan YR, Wen Y, Du FL, Li M, Wang ZX, Yang ZJ.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Spatiotemporal transferability of multi-temporal random forest model for mapping <i>Euryale ferox</i> Salisb. plantations using Sentinel-2 imagery. [PDF]

Front Plant Sci
Zhang K, Wang S, Chen C, He X, Cai M, Li X, Long J, Wang X.   +7 more
europepmc   +1 more source

Clinical, endoscopic, and pathological features of synchronous multiple early-stage colorectal cancer: a two-center retrospective case-control study. [PDF]

Front Med (Lausanne)
Zeng R, Guo X, Ning J, Lin X, Zhang J, Gu F, Liu X, Meng Q, Li H, Zhang Y, Ding S.   +10 more
europepmc   +1 more source

Composite Blood-Count Inflammatory Indices in Diabetic Kidney Disease and Advanced, Largely Dialysis-Dependent Non-Diabetic Chronic Kidney Disease: A Single-Centre, Four-Group Cross-Sectional Study. [PDF]

J Clin Med
Acet A, Tezcan N.
europepmc   +1 more source

Development and cross-cohort evaluation of a <i>DLX4</i>-associated epithelial-mesenchymal transition pathomics signature for overall survival in clear cell renal cell carcinoma. [PDF]

Transl Androl Urol
Fang G, Bao X, Chang J, Sun F, Qiu Z.
europepmc   +1 more source

Genomic dissection of environmental responsiveness and cross-environment productivity in fenugreek. [PDF]

PLoS One
Aljabri M, Abd El-Wahab MMH, Dobeie AM, El-Soda M.   +3 more
europepmc   +1 more source