Results 91 to 100 of about 7,150,473 (243)

Order acceptance and scheduling in a single-machine environment: exact and heuristic algorithms. [PDF]

In this paper, we develop exact and heuristic algorithms for the order acceptance and scheduling problem in a single-machine environment. We consider the case where a pool consisting of firm planned orders as well as potential orders is available from ...
Herbots, Jada, Leus, Roel, Talla Nobibon, Fabrice   +2 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Rate-of-change analysis applied to machine tool monitoring and maintenance schedules [PDF]

, 2012
In high-value manufacturing, production equipment is often calibrated on a regular basis to ensure it remains within the required absolute tolerance. However, this go/no go approach means that data relating to the rate of change of the condition of the ...
Longstaff, Andrew P., Machine Tool Technologies ltd., Fletcher, Simon, Willoughby, Peter, Perkins, Christopher   +4 more
core   +2 more sources

Single Machine Scheduling Based on EDD-SDST-ACO Heuristic Algorithm

Journal of Intelligent Systems, 2017
A large number of changeovers exist in multi-item and small lot size production mode, which lead to a long setup time and significantly influence productivity.
Song Haicao, Yi Shuping, Liu Mi, Qin Gaoyang   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Experiments on domain adaptation for patent machine translation in the PLuTO project [PDF]

, 2011
The PLUTO1 project (Patent Language Translations Online) aims to provide a rapid solution for the online retrieval and translation of patent documents through the integration of a number of existing state-of-the-art components provided by the project ...
Tinsley, John, Zhang, Jian, Way, Andy, Ceausu, Alexandru   +3 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Scheduling in stochastic bicriteria single machine systems with job-dependent learning effects

Kuwait Journal of Science, 2013
A stochastic bicriteria single machine scheduling problem with job-dependent learning effects in which the normal processing times of jobs (i.e., processing times without any learning effects) are random variables was studied.
H. M. SOROUSH, F. O. AMIN
doaj